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    Did you mean PPAR Agonists?
    Glossary PPAR Agonists

    activate nuclear receptors to regulate metabolism and inflammation

    PPAR Agonists, or Peroxisome Proliferator-Activated Receptor Agonists, are compounds that activate PPARs, which are nuclear receptor proteins that regulate gene expression. These receptors play a crucial role in metabolism, inflammation, and cell differentiation, making PPAR agonists valuable in treating conditions like diabetes, obesity, and certain types of hair loss, such as alopecia.

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    Research 10 of 1000+

    1. Functions of peroxisome proliferator‐activated receptors (PPAR) in skin homeostasis Lipids · 2004 · 46 citations
    2. Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P The FASEB Journal · 2001 · 125 citations
    3. Pathogenic Mechanisms and Mechanism‐Directed Therapies for Androgenetic Alopecia: Current Understanding and Future Directions Dermatologic Therapy · 2025
    4. Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α Journal of Neuroendocrinology · 2011 · 52 citations
    5. Early skin seeding regulatory T cells modulate PPARγ-dependent skin pigmentation bioRxiv (Cold Spring Harbor Laboratory) · 2023
    6. Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia Molecular and Cellular Endocrinology · 2016 · 47 citations
    7. The promotion of hair regrowth by topical application of a Perilla frutescens extract through increased cell viability and antagonism of testosterone and dihydrotestosterone Journal of Natural Medicines · 2017 · 8 citations
    8. PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology Experimental Dermatology · 2019 · 24 citations
    9. Cicatricial alopecia: What’s new in etiology? European Journal of Inflammation · 2015
    10. Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics? Archives of dermatological research · 2015 · 60 citations
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    Community 1 of 5

    1. DHT Oily Scalp Dangers: Theory of an Oily Scalp and PPAR-GAMMA Dysregulation Reddit · 3 Mar 2025
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