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research Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia

7 citations , November 2014 in “Histochemistry and Cell Biology”

This study found that mutant mice with the we/we wal/wal genotype exhibit significant defects in hair shaft structure and epidermis stratification, correlating with postnatal alopecia symptoms.

research Targeted Expression of Human Vitamin D Receptor in the Skin Promotes the Initiation of the Postnatal Hair Follicle Cycle and Rescues the Alopecia in Vitamin D Receptor Null Mice

57 citations , April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that the vitamin D receptor is crucial for initiating the postnatal hair follicular cycle in mice, preventing alopecia associated with its inactivation.

research Expression of beta-catenin, p63 and CD34 in hair follicles during the course of androgenetic alopecia

4 citations , August 2005 in “Archives of Dermatological Research”

This study detected higher expression of p63 in occipital scalp areas compared to frontal areas, with minimal changes in beta-catenin expression and a novel finding of CD34 positive cells in hair follicles' outer root sheath.

research Inhibition of class I HDACs preserves hair follicle inductivity in postnatal dermal cells

6 citations , December 2021 in “Scientific Reports”

This study found that inhibiting class I histone deacetylases in postnatal mouse dermal cells preserved their ability to induce hair follicles during culture by increasing specific gene expressions and activating the Wnt signaling pathway.

research Generation of Hair Follicle Germs In Vitro Using Human Postnatal Skin Cells

2 citations , January 2020 in “Methods in molecular biology”

This study describes a protocol for generating hair follicle germ-like organoids from human skin cells, which may aid in alopecia drug discovery and understanding hair follicle regeneration.

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Community Join

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Severe Hair Loss Post-Surgery and Stress, Possible DUPA or Alopecia?

in General 64 upvotes 10 months ago

The user is experiencing severe hair loss after surgery and stress, with thinning all over the head, including the sides and neck. They are unsure if it's due to DUPA or alopecia areata incognita, and doctors have not observed miniaturization.

community Opinions- AGA options and pregnancy

in Female 7 upvotes 2 years ago

A user with Androgenetic Alopecia is seeking advice on hair growth treatments while planning for pregnancy. Current routine includes LaserCap, Nizoral Shampoo, scalp massage, The Ordinary Multi Peptide Serum, vitamin D, prenatal vitamins, and SEEN shampoo.

community 8 months post HT: weird asymmetrical shedding/recession?. Dr not 100% sure cause. Theories??

in Transplants 10 upvotes 2 years ago

8 months post hair transplant, OP experiences asymmetrical shedding despite using finasteride and starting minoxidil. The doctor suggests it might correct itself or be due to transplant trauma, recommending a wait-and-see approach.

community Telogen Effluvium

4 upvotes 8 years ago

Hair regrowth after telogen effluvium, with the user experiencing hair loss at the temples and regrowth after taking omega-3/fish oil tablets. Suggestions include consulting a dermatologist and considering supplements like Biotin, Zinc, and Vitamin D.

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Learn

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learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn GHK-Cu

Do alopecia areata patches scar? And is there evidence for peptides? Alopecia areata patches usually still have living follicles and often regrow. One small trial of a cosmetic peptide lotion reported improvement, but no peptide is an approved treatment; see a dermatologist.

learn PP405

Can PP405 help bald patches caused by stress? PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

learn Bimatoprost

What do the latest studies say about bimatoprost for scalp hair growth? Bimatoprost is approved only for eyelashes; a 30-person pilot found it beat a topical steroid on patches of alopecia areata, but the two registered Allergan trials in male pattern hair loss were never published and never taken further, so scalp use stays off-label and experimental.
Is bimatoprost effective for people with alopecia areata? Bimatoprost is approved only for eyelashes; for alopecia areata the evidence is a few small studies with mixed results. Near the eyes it can darken the iris, a change its label says is likely to be permanent.

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