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5 / 801 resultslearn Keratin
learn SCUBE3
a signaling molecule from dermal papilla cells being actively researched
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learn platycladus orientalis
Research
5 / 32 resultsresearch Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System
The document outlines a protocol for generating human induced pluripotent stem cell-derived skin organoids (SOs) with hair follicles using an air-liquid interface (ALI) culture system. Initially developed in an inverted cystic form, these SOs are transformed into a planar configuration that better mimics human skin. The protocol includes checkpoints for assessing organoid development, steps for flattening cystic SOs, and optimal ALI culture conditions. By Day 27, the organoids exhibit a pluristratified pigmented epithelium with hair follicles and sebaceous gland-like structures. This method provides a physiologically relevant in vitro model for skin research, applicable in studies of pathogen infection, UV-induced damage, and drug responses.
research Hair follicle stem cells: Walking the maze
Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.
research Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells
Scientists created stem cells that can grow hair and skin.
research Therapeutic Potential of Patient iPSC-Derived iMelanocytes in Autologous Transplantation
Patient-derived melanocytes can potentially treat vitiligo by restoring skin pigmentation.
research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia
Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.
Community Join
5 / 1000+ resultscommunity Hair and normal skin created from human pluripotent stem cells for the first time
Human pluripotent stem cells have been used to create hair and skin, potentially offering a new solution for baldness. A user also mentioned starting finasteride but experiencing unexpected hair thinning.
community What is this pigmentation around my follicles?
The conversation discusses potential causes of pigmentation around hair follicles, suggesting sebum buildup, autoimmune conditions, or dermatitis. Treatments mentioned include finasteride, dutasteride, and an anti-inflammatory diet, with a recommendation to consult a doctor for a proper diagnosis.
community Scalp Micropigmentation while having hair
User discusses scalp micropigmentation for denser hair appearance and its benefits compared to lifelong treatments. Special ink is used, which can fade and blur over time but can be topped up.
community Hair repigmentation of poliosis circumscripta in androgenetic alopecia patient treated with exosomes and fractional picosecond laser
Exosomes combined with fractional picosecond laser treatment were effective in treating androgenetic alopecia and promoting repigmentation in white hair patches. The role of exosomes in hair repigmentation, particularly in conditions like poliosis, is not well-studied.
community Pelage Recruiting Now for Phase 2
Pelage is recruiting for phase 2 trials, showing promise for treating bald regions. The discussion highlights its potential effectiveness based on its mechanism of action.