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In this study, researchers presented a protocol for generating planar skin organoids from human induced pluripotent stem cells, which include hair follicles and other skin structures, offering a relevant in vitro model for investigating skin physiology, pathogen interactions, and drug responses.

This review discusses the various stem cell populations associated with hair follicles and their potential in regenerative medicine, highlighting differences between murine and human hair follicles but reports no new clinical results.

In this study, researchers developed a method to differentiate human iPSCs into cells that can generate all lineages of hair follicles, potentially aiding treatments for hair loss and skin disorders.

This study found that human iPSC-derived melanocytes from vitiligo patients successfully integrated into mouse hair follicles and epidermis, demonstrating potential for personalized therapy for depigmentation.

This study found that overexpression of the mineralocorticoid receptor in a mouse model led to premature epidermal barrier development, keratinocyte apoptosis, and postnatal alopecia, indicating new roles for MR signaling in skin physiology.