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research Efficacy and safety of topical finasteride spray solution in the treatment of Chinese men with androgenetic alopecia: A phase III, multicenter, randomized, double-blind, placebo-controlled study

March 2025 in “Chinese Medical Journal”

This randomized, double-blind, placebo-controlled phase III trial found that a 24-week treatment with topical finasteride significantly increased hair growth and was well-tolerated in Chinese men with androgenetic alopecia compared to placebo.

research A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss

219 citations , March 2004 in “Journal of The American Academy of Dermatology”

In this 48-week trial, 5% topical minoxidil was more effective than both 2% minoxidil and placebo in promoting hair growth in women with female pattern hair loss, with notable improvements in nonvellus hair count and hair growth assessments.

research A Randomized, Double-Blind, Placebo and Active Controlled Phase II Study to Evaluate the Safety and Efficacy of Novel Dutasteride Topical Solution (0.01%, 0.02%, and 0.05% w/v) in Male Subjects With Androgenetic Alopecia

August 2025 in “Cureus”

This phase II study found that a 0.05% topical dutasteride solution was more effective than oral finasteride (1 mg/day) in increasing hair count and width in males with androgenetic alopecia over 24 weeks, without causing irritation.

research The German Double‐Blind Placebo‐Controlled Evaluation of Topical Minoxidil Solution in the Treatment of Early Male Pattern Baldness

17 citations , July 1988 in “International Journal of Dermatology”

In this study, 2% minoxidil solution was found to be a safe and more effective treatment for early male pattern baldness compared to placebo.

research Microneedling plus topical dutasteride solution for androgenetic alopecia: a randomized placebo‐controlled study

June 2022 in “Journal of The European Academy of Dermatology and Venereology”

This study reports no results yet and only indicates an ongoing randomized placebo-controlled trial investigating the effects of microneedling combined with topical dutasteride solution for treating androgenetic alopecia.

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Community Join

5 / 875 results

community Solution for male pattern baldness

245 upvotes 9 months ago

A new hair loss treatment claims a 539% improvement over placebo, but skepticism remains due to lack of substantial evidence and reliance on percentage figures. Users discuss the effectiveness of existing treatments like Minoxidil and Finasteride, expressing doubt about the new solution's impact.

community Clascoterone ph3 results ready

10 upvotes 9 months ago

Clascoterone 5% solution showed a 539% improvement in hair count compared to placebo, but the actual increase in hair growth is minimal. Users express skepticism about the effectiveness of hair loss treatments.

community The urge to buy Clascoterone 5% solution

11 upvotes 9 months ago

Clascoterone 5% solution is not yet commercially available, with only the 1% solution currently sold for acne. Users discuss the potential of Clascoterone as a hair loss treatment, comparing it to other anti-androgens like RU58841 and Eucapil.

community What’s your views on clascoterone 5% topical solution by cosmo

23 upvotes 9 months ago

Clascoterone 5% topical solution shows promise for treating male-pattern hair loss by blocking DHT at the follicle without systemic absorption, potentially offering fewer side effects than oral treatments like finasteride. While results are promising, long-term safety and effectiveness need further study, and it may serve as a starting point for developing more effective treatments.

community Question about ppl who use Hair+ me topical solution

in Research/Science 4 upvotes 5 months ago

Minoxidil and finasteride topical solutions may last longer than their labeled best before date, with users experiencing varying side effects and effectiveness over time. Some users report reduced side effects and increased hair loss towards the end of the second month of use.

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Learn

5 / 22 results

learn Melatonin

Hormone that regulates sleep, sold as a supplement

Is melatonin better as a supplement or applied to the scalp? No study has compared oral and topical melatonin head to head. Topical melatonin has one small placebo-controlled pilot trial in 40 women plus a set of mostly uncontrolled studies of a cosmetic solution; oral melatonin has no published hair-loss trial at all.

learn Clascoterone

Topical androgen-receptor blocker, approved as an acne cream

learn Platelet-Rich Plasma

Concentrate of your own blood platelets, injected into the scalp

learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

learn Neem Oil

Oil from the neem tree, used in traditional remedies

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