Search

for
Search:

Research

5 / 1000+ results

research A regulatory perspective on pharmacokinetic/pharmacodynamic modelling

18 citations , June 1999 in “Statistical Methods in Medical Research”

This paper reviews the role of pharmacokinetic/pharmacodynamic modeling in drug development, emphasizing its application for drug dosing guidance, safety resolution, and therapeutic monitoring improvement, without presenting new clinical results.

research Development and Qualification of a Physiologically Based Pharmacokinetic Model of Finasteride and Minoxidil Following Scalp Application

4 citations , February 2021 in “Journal of Pharmaceutical Sciences”

This study suggests that the developed PBPK model effectively predicts pharmacokinetic and pharmacodynamic profiles of topical finasteride and minoxidil on the scalp, indicating potential broader applicability for other formulations.

Pharmacokinetic-Pharmacodynamic Modeling Approach for Dose Prediction of the Optimal Long-Acting Injectable Formulation of Finasteride

research Pharmacokinetic-pharmacodynamic modeling approach for dose prediction of the optimal long-acting injectable formulation of finasteride

6 citations , March 2021 in “International Journal of Pharmaceutics”

This study reported that a subcutaneous injection formulation using PLGA microspheres to release finasteride stably achieved sustained monthly drug delivery without burst release in beagle dogs, with a dose of 16.8 mg identified as optimal for potential first-in-human trials.

research Evolution of Ritlecitinib Population Pharmacokinetic Models During Clinical Drug Development

6 citations , November 2023 in “Clinical Pharmacokinetics”

This research discusses the parallel clinical development of ritlecitinib, an oral Janus kinase 3/tyrosine kinase inhibitor, for treating conditions such as alopecia areata, vitiligo, ulcerative colitis, Crohn's disease, and rheumatoid arthritis. Results are not reported in the abstract.

Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-Linear Pharmacokinetics

research Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic (TMDD-PD) Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-linear Pharmacokinetics

December 2025 in “The AAPS Journal”

Finasteride and dutasteride's effects are mainly due to target binding saturation and slow enzyme turnover.

View more "pharmacokinetic model" in research →

Community Join

5 / 77 results

community Clascoterone - what we have right now

24 upvotes 6 months ago

Clascoterone is a topical treatment for androgenetic alopecia, showing modest to moderate hair regrowth, and may be available by 2027-2028. It is considered safer than finasteride, with discussions on its effectiveness compared to RU58841 and pyrilutamide.

community Research Backed Dutasteride Simulator (Serum/Scalp DHT included for all doses)

116 upvotes 1 year ago

A dutasteride simulator predicts that daily 0.5 mg dosing results in higher DHT suppression compared to less frequent dosing. Twice-weekly dutasteride may be as effective as finasteride 5 mg, providing a balance between efficacy and ease of use.

community DHT reduction in the scalp for all doses of dutasteride is now available.

in Finasteride/Dutasteride 357 upvotes 1 year ago

Higher doses of dutasteride reduce scalp DHT more effectively than finasteride, but have diminishing returns after 3mg daily and may cause more side effects. Combining dutasteride with topical minoxidil can enhance results, but using both finasteride and dutasteride together is unnecessary.

community New and Interesting HairLoss Studies/Papers/Reviews

44 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Dutasteride half life - conflicting information

9 upvotes 2 years ago

The half-life of Dutasteride is commonly stated as around 5 weeks, but some sources suggest it is 170 hours for men aged 20–49, with further information indicating it varies from 3 days to 5 weeks depending on the dose. The user is seeking clarity on these conflicting figures.

View more "pharmacokinetic model" in community →

Learn

1 / 801 results

learn Overview

View more "pharmacokinetic model" in learn →

Clinics

6 / 70 results

All 70 clinic results →

Experts

— no results

Try a deeper search in experts →