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research Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects

2 citations , November 2022 in “Scientific reports”

This study found that gelatin sponges used as scaffolds in rats with deep wounds and periosteal defects enabled regeneration of diverse tissue types, including periosteum, skin, and appendages, highlighting the role of vascular niche formation.

research The periosteal requirement and temporal dynamics of BMP2‐induced middle phalanx regeneration in the adult mouse

31 citations , June 2017 in “Regeneration”

This study found that applying BMP2 stimulated limited regeneration of the amputated P2 bone in mice, but only when applied during a specific "regeneration window" after injury.

research The effect of minocycline on the metabolism of androgens by human oral periosteal fibroblasts and its inhibition by finasteride

10 citations , April 2000 in “Archives of Oral Biology”

Minocycline may cause hair loss by increasing DHT levels, but finasteride can help counteract this effect.

research Osteosclerosis and periostal new bone formation during indinavir therapy

7 citations , March 2002 in “AIDS”

This case report presents an HIV-1 patient who experienced osteosclerosis and new bone formation potentially due to long-term indinavir therapy and concurrent use of vitamin A, with symptoms reducing after switching to nelfinavir.

research Cytokine profiles associated with persisting symptoms of post-acute sequelae of COVID-19

July 2025 in “The Korean Journal of Internal Medicine”

This study suggests that T-cell recruitment, thrombosis, and increased vascular permeability may contribute to various symptom clusters in post-acute sequelae of COVID-19 through shared cytokine elevation.

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community Oral Minoxidil Shed Persisting for Almost a year

4 upvotes 5 days ago

The user has been experiencing persistent hair shedding for almost a year after starting oral minoxidil 2.5 mg, despite being on oral finasteride 1 mg for over a year. They report major thinning, especially at the hairline, and are seeking advice on similar experiences.

community Oral Min shed is brutal . Do I keep going?

in Minoxidil 94 upvotes 1 year ago

The conversation discusses the experience of hair shedding after starting sublingual oral Minoxidil, with the user questioning whether to continue the treatment. Responses suggest persisting with the treatment as shedding might lead to positive results.

community fin 0.5 mg everday 6 months update

in Finasteride/Dutasteride 28 upvotes 2 years ago

The post discusses the experiences of individuals with diffuse hair thinning using finasteride, with many reporting no improvement or worsening conditions after 6 months. Various suggestions include persisting with the treatment, checking for underlying conditions, adding minoxidil for volume, adjusting dosage, and considering other potential causes like autoimmune responses and inflammation.

community Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive

6 upvotes 2 months ago

Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

What role does Osteopontin play in protecting and repairing hair follicles? Osteopontin protects and repairs hair follicles by signaling cells to survive and recover.

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