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GlossaryPerifollicular Inflammation

swelling and irritation around hair follicles

Perifollicular inflammation refers to the swelling and irritation that occurs around hair follicles. This condition can lead to hair loss and is often seen in various types of alopecia, such as alopecia areata. It involves immune cells attacking the hair follicles, which can disrupt normal hair growth and cause damage to the follicle structure.

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Evaluation of Perifollicular Inflammation of Donor Area During Hair Transplantation in Androgenetic Alopecia and Its Comparison With Controls

research Evaluation of Perifollicular Inflammation of Donor Area During Hair Transplantation in Androgenetic Alopecia and Its Comparison With Controls

13 citations, January 2013 in “International Journal of Trichology”

Inflammation around hair follicles may worsen hair loss; evaluating and treating it can improve transplant results.

research Perifollicular Inflammation and Follicular Spongiosis in Androgenetic Alopecia

1 citations, September 2021 in “Journal of The American Academy of Dermatology”

Hair loss in both Androgenetic Alopecia and Alopecia Areata is often accompanied by inflammation around hair follicles, but the location and severity of this inflammation varies.

research Biological Effects of Electrical Epilation on Human Hair Follicles and Perifollicular Skin Ex Vivo

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Electrical epilation damages hair follicles and surrounding skin, likely preventing hair regrowth.

Low-Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% for Sustainable Hair Regrowth

research Low-Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% for Sustainable Hair Regrowth

4 citations, May 2021 in “Lasers in Surgery and Medicine”

Light therapy reduces scalp inflammation, boosts hair regrowth with Minoxidil 2%.

research Substance P in Keratosis Follicularis Spinulosa Decalvans

4 citations, September 2015 in “JAAD case reports”

Substance P may play a role in the inflammation seen in keratosis follicularis spinulosa decalvans.

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community I’ve lost about 50% of my hair in 5 months. This is after 2 years of fin

in Finasteride/Dutasteride 16 upvotes 8 months ago

The user is experiencing significant hair thinning and scalp discomfort after two years on finasteride and is considering switching to dutasteride. Another person suggests that scalp inflammation might be the cause and recommends a YouTube channel for more information.

community Eliminating scalp itch leads to regrowth (and my RU58841 progress)

in Research/Science 63 upvotes 1 year ago

User experienced hair regrowth after eliminating scalp itch with RU58841. Others discussed itch and hair loss connection, and effectiveness of combining RU58841 with 5AR inhibitors.

community I just want to say Ru58841 saved my life.

in Chat 28 upvotes 1 year ago

A user's experience with hair loss and scalp inflammation, which was alleviated by using RU58841 along with finasteride and dutasteride. A theory of inflammation possibly being a cause of hairloss is also discussed.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 1 year ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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