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GlossaryPerifollicular Infiltrate

accumulation of immune cells around hair follicles

Perifollicular infiltrate refers to the accumulation of immune cells around hair follicles. This can be a sign of inflammation or an immune response, often seen in conditions like alopecia areata, where the body's immune system mistakenly attacks hair follicles, leading to hair loss.

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The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

18 citations, January 2017 in “Annals of dermatology/Annals of Dermatology”

Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.

research Whole Exome Sequencing in Alopecia Areata Identifies Rare Variants in KRT82

9 citations, February 2022 in “Nature communications”

Rare changes in the KRT82 gene are linked to a higher risk of Alopecia Areata.

research Topical Minoxidil in Alopecia Areata: No Effect on the Perifollicular Lymphoid Infiltration

33 citations, July 1992 in “Journal of Investigative Dermatology”

Minoxidil doesn't affect perifollicular lymphoid infiltration in alopecia areata patients.

research High-Throughput T Cell Receptor Sequencing Identifies Clonally Expanded CD8+ T Cell Populations in Alopecia Areata

46 citations, October 2018 in “JCI insight”

CD8+ T cells are involved in alopecia areata and may cause disease relapse.

research Frontiers in Alopecia Areata Pathobiology Research

55 citations, October 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.

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community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 13 upvotes 4 months ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community Novel effect of sildenafil (cialis) on hair growth

in Research/Science 21 upvotes 2 years ago

Sildenafil (Viagra) shows potential for hair growth by enhancing dermal papilla cell proliferation and stimulating perifollicular vessel formation. Users discuss the possibility of using Cialis (tadalafil) similarly, noting its benefits and side effects.

community Does 0.5 mg of finasteride reduce SCALP DHT the same as 1 mg?

in Finasteride/Dutasteride 15 upvotes 3 months ago

The conversation is about whether 0.5 mg of finasteride reduces scalp DHT as effectively as 1 mg. Users suggest that even lower doses like 0.05 mg can significantly reduce scalp DHT.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 1 year ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community I just want to say Ru58841 saved my life.

in Chat 28 upvotes 1 year ago

A user's experience with hair loss and scalp inflammation, which was alleviated by using RU58841 along with finasteride and dutasteride. A theory of inflammation possibly being a cause of hairloss is also discussed.

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