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A Proposed Etiopathology of Persistent Dysfunctions Emerging from Use and Discontinuation of 5-Alpha Reductase Inhibitors: Sequelae of Drug-Mediated Microvasculopathy

research A Proposed Etiopathology of Persistent Dysfunctions Emerging from Use and Discontinuation of 5-Alpha Reductase Inhibitors: Sequelae of Drug-Mediated Microvasculopathy

February 2022

The document suggests that drugs for prostate issues might cause lasting sexual, mental, and physical health problems due to blood vessel damage in the penis.

Long-Term Oral Administration of 5α-Reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats

research Long-Term Oral Administration of 5α-Reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats

34 citations, September 2013 in “Urology”

Long-term use of a certain medication can worsen erectile function in aged rats by damaging penile muscle cells.

research The Post-Finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption

8 citations, July 2018 in “Current Sexual Health Reports”

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

research Gender-Affirming Hormone Therapy for Transgender Females

32 citations, September 2018 in “Clinical Obstetrics and Gynecology”

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

research Sexual Dysfunction in Men Taking Systemic Dermatologic Medication: A Systematic Review

11 citations, March 2019 in “Journal of The American Academy of Dermatology”

Some men taking finasteride for hair loss may experience sexual problems like erectile dysfunction and decreased sex drive, which can persist even after stopping the medication.

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community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community FtM: "Aggressive Regemin - Recovery From Norwood-6.5" Minoxodil/Estradiol valerate/Spironolactone. (What will happen in the worst case if CIS male go this way for a year?)

in Progress Pictures 55 upvotes 3 years ago

User "Ant1pal" shares progress pictures of hair regrowth using Minoxidil, Estradiol valerate, and Spironolactone. Users discuss potential side effects and the possibility of localizing estrogen to hair follicles for better treatment.

community Why I believe PFS is not a "real" condition (and what I believe it is instead)

in Finasteride/Dutasteride 14 upvotes 2 years ago

The post argues that Post-Finasteride Syndrome (PFS) is likely not real and suggests symptoms may be due to mental health issues or the nocebo effect. The conversation includes personal experiences with finasteride, highlighting both positive and negative effects, and emphasizes consulting doctors and using reliable sources for medication.

community What other factors than DHT causes hair loss – and what to do about it?

in Treatment 2 years ago

Factors that can cause hair loss other than DHT, such as inflammation and diet, and potential treatments like scalp massages, minoxidil, citrulline, stretches, meditation, iron sulfate/Vitamin C, Vitamin D, protein and Dutasteride.

community Used finasteride 10 years ago and I still suffer from severe ED. I have blood test results attached

in Finasteride 10 upvotes 6 years ago

A user took finasteride for hair loss 10 years ago, stopped after a month, and has since suffered from severe erectile dysfunction (ED) and other symptoms. They shared blood test results seeking advice for their condition, and others discussed similar experiences with finasteride and related drugs.

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