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Glossary Patch Testing

diagnostic method to identify skin allergies to specific substances

Patch testing is a diagnostic procedure used to identify substances that cause allergic contact dermatitis. Small amounts of potential allergens are applied to patches, which are then placed on the skin, usually on the back, for 48 hours. The skin is examined for reactions at 48 hours and again at 72-96 hours to determine if an allergy is present.

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Research

5 / 1000+ results

research Patch tests with commercial hair dye products in patients with allergic contact dermatitis to para-phenylenediamine

6 citations , January 2016 in “Indian Journal of Dermatology Venereology and Leprology”

This study found that the majority of "hypoallergenic" hair dyes still triggered allergic reactions in patients sensitive to para-phenylenediamine.

research Influence of Atopic Dermatitis on the Dermoscopic Phenotype of Positive Patch Test Reactions: A Prospective Comparative Study

April 2026 in “Life”

In this study, researchers observed that atopic dermatitis may alter the appearance of allergic patch test reactions, demonstrating specific patterns like perifollicular erythema and yellowish areas that could aid in interpreting patch tests using dermoscopy, particularly in ambiguous cases.

research Patch test positive results in patients with biopsy‐proven central centrifugal cicatricial alopecia

June 2024 in “Journal of the European Academy of Dermatology and Venereology”

This abstract provides information on potential conflicts of interest and acknowledges sources of support for the findings, but does not report specific study results.

research Common Allergens Identified Based on Patch Test Results in Patients with Suspected Contact Dermatitis of the Scalp

16 citations , December 2016 in “Skin appendage disorders”

This study analyzed patch test results to identify allergens causing scalp contact dermatitis, finding nickel, cobalt, and balsam of Peru among the most common in the patient population.

research Ethanol Patch Test—A Simple and Sensitive Method for Identifying ALDH Phenotype

66 citations , April 1989 in “Alcoholism Clinical and Experimental Research”

This study found that the ethanol patch test effectively indicates the ALDH phenotype in healthy Japanese individuals, suggesting its usefulness for future research.

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Community Join

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community Is anybody here combining oral dutasteride with topical dutasteride?

in Finasteride/Dutasteride 9 upvotes 2 years ago

A user is considering combining oral and topical dutasteride to lower scalp DHT more effectively and is seeking advice on this approach. They are thinking about doing a patch test on their mid scalp.

community Ray Peat: Testosterone Isn’t the Culprit, Prolactin and Cortisol Drive Hair Loss (2016)

in Research/Science 110 upvotes 10 months ago

Prolactin and cortisol are identified as key factors in hair loss, with stress hormones impacting hair shedding. Finasteride and minoxidil are effective treatments, while DHT's role and individual sensitivity are significant factors.

community Take licorice to lower testosterone?

1 upvotes 9 years ago

Licorice is not recommended for hair loss as it inhibits hair growth and is a non-selective testosterone inhibitor. Alternatives like spironolactone are suggested for those considering hormonal treatments for hair loss.

community Testosterone in Reference Range Doesn't Cause Hair Loss

52 upvotes 2 years ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community Does finasteride decrease free testosterone?

in Research/Science 186 upvotes 1 year ago

Finasteride may decrease free testosterone by increasing SHBG, potentially causing side effects like reduced libido and hormonal changes. Some find it effective for hair loss, while others experience negative effects.

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Learn

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learn Scalp Micropigmentation

Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.

learn Ecklonia Cava

Is Ecklonia Cava safe for sensitive or irritated scalps? Ecklonia cava may irritate sensitive scalps, so patch test first.

learn sh-Polypeptide-7

Are there any safety concerns or allergic reactions associated with sh-Polypeptide-7 in topical hair products? There are no published human studies on sh-Polypeptide-7 itself, so its safety is unestablished; research on cosmetic peptides as a class reports low irritation and rare allergy, and dermatologists advise patch testing a new scalp product.

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Overview

learn Vitamin D

vitamin you should probably be taking for general health might also help your hair a little

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Baicapil

Struggling with patchy hair loss like alopecia areata? Baicapil might help by reducing inflammation and reactivating growth. There is no published trial of Baicapil in alopecia areata. The anti-inflammatory and hair-density claims come from the ingredient's manufacturer and from laboratory work on its plant extracts, in people with androgenetic-type hair loss rather than autoimmune patchy hair loss.

learn Baricitinib

Baricitinib: Can I use it even if I don’t have a medical diagnosis but I have patchy hair loss? Use baricitinib only with a medical diagnosis of alopecia areata.

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