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This study observed that activating the Wnt/β-catenin pathway enhances hair follicle stem cell proliferation and differentiation, promoting hair growth and wound healing, and demonstrated the potential for outer root sheath transplants to aid skin repair, although challenges remain for clinical application.

This study found that isolated hair follicle outer root sheaths from mice can regenerate new dermal papillary structures in vitro, with stem cells and neutrophils playing key roles in the regeneration process.

This study found that anagen hair follicles can quickly regenerate after radiation damage by forming new progenitor cells outside the bulge, bypassing the need for telogen entry.

This study suggests that human outer root sheath cells are suitable for skin replacement, as they can form a stratified epithelium similar to normal epidermis in organotypic cultures.

This study reports that EGF at specific concentrations promotes the proliferation and migration of hair follicle ORS cells by activating the Wnt/β-catenin signaling pathway in vitro.