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research Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata

196 citations , September 2016 in “JCI insight”

This study explored the effectiveness of the oral JAK1/2 inhibitor ruxolitinib in treating patients with moderate-to-severe alopecia areata, building on prior success with JAK inhibitors in mice, but results are not reported in this abstract.

Topical Ruxolitinib in Combination with Oral Minoxidil Results in Hair Regrowth in a Patient with Central Centrifugal Cicatricial Alopecia and Concomitant Traction Alopecia

research Topical Ruxolitinib in Combination with Oral Minoxidil Results in Hair Regrowth in a Patient with Central Centrifugal Cicatricial Alopecia and Concomitant Traction Alopecia

April 2025 in “JAAD Case Reports”

This review discusses central centrifugal cicatricial alopecia in adult women of African descent and reports no clinical results; the authors highlight traditional treatments and their impact on quality of life.

research Rapid skin repigmentation on oral ruxolitinib in a patient with coexistent vitiligo and alopecia areata (AA)

157 citations , December 2015 in “Journal of the American Academy of Dermatology”

This case study reported significant but temporary hair regrowth and skin repigmentation in a patient with vitiligo and alopecia areata during treatment with oral ruxolitinib.

research A Case of Topical Ruxolitinib Treatment Failure in Alopecia Areata

30 citations , June 2017 in “Journal of cutaneous medicine and surgery”

This study reports that topical ruxolitinib failed to induce hair growth in a 66-year-old patient with alopecia areata, highlighting the need to explore factors affecting treatment response and compare topical vs oral administration outcomes.

research Oral and Topical Janus Kinase Inhibitors in Patients With Cutaneous T‐Cell Lymphoma: A Real‐World Single‐Center Experience

April 2025 in “The Journal of Dermatology”

This study provides initial insights into the use of JAK inhibitors for CTCL, reporting some cases of symptom improvement, but highlights the need for further research on their association with CTCL development and safety.

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Community Join

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community I had claude create a protocol only using fda approved drugs.

4 upvotes 8 months ago

A new hair loss protocol using FDA-approved topical treatments targets eight pathways, potentially improving results by 60-75% compared to the standard 40-50% from oral minoxidil and finasteride. The protocol includes minoxidil, finasteride, tacrolimus, cetirizine, bimatoprost, lithium gluconate, losartan, melatonin, NAC, caffeine, and tretinoin, with a monthly cost of $35-50 in Mexico and $80-150 in the US.

community What else is good. Besides the big 3.

in Chat 35 upvotes 1 year ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community What if DHT is not the vilan.

13 upvotes 5 years ago

Hair loss may be influenced more by inflammation, microbiome imbalances, and gut health than DHT. Treatments discussed include minoxidil, finasteride, RU58841, fecal microbiota transplants, and JAK inhibitors.

community How much does oral minoxidil and finsteride cost you?

1 upvotes 1 day ago

Oral minoxidil and finasteride costs vary, with some users reporting $18 for 90 days of finasteride and $31 for 90 days of minoxidil through Amazon. Splitting higher-dose pills can reduce costs to $20-40.

community Facial bloating/aging on oral Min

4 upvotes 4 days ago

Oral minoxidil can cause facial bloating, leading to a puffy appearance. Some users report improvement after stopping the medication.

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Learn

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learn Tofacitinib

a JAK inhibitor for alopecia areata and other autoimmune conditions

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.

learn Metformin

Is metformin used topically for hair loss, or only as an oral tablet? Approved metformin products are oral tablets only; there is no approved topical metformin for hair loss. Published human reports of topical use are a handful of uncontrolled, pharmacy-compounded case reports in scarring alopecia, and the most-cited clinical series actually used the oral drug.

learn Sulforaphane

Is sulforaphane used in oral supplements or topical hair treatments? Sulforaphane is primarily used in oral supplements, not topical hair treatments.

learn white tea

Is white tea more effective in topical hair products or as an oral supplement for hair growth? Neither topical nor oral white tea has any human clinical trial behind it for hair growth. Topical use has a more direct mechanistic rationale, but the only verifiable studies are a cell-culture EGCG experiment and a pharmacokinetic study with no hair outcomes.

learn Estradiol

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.

learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

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