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Glossary Olfactory Receptor

specialized protein in the nose that detects odors

An olfactory receptor (OR) is a specialized protein found in the sensory neurons of the nose that detects odor molecules. When an odor molecule binds to an olfactory receptor, it triggers a signal that is sent to the brain, allowing us to perceive and identify different smells. These receptors are part of a large family of G-protein-coupled receptors and are crucial for the sense of smell.

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Research

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Activation of Olfactory Receptor 2A4/7 by Cyclohexyl Salicylate Promotes Human Hair Follicle Growth

research 572 Olfactory Receptor 2A4/7 Activation by the Fragrance, Cyclohexyl Salicylate, Promotes Human Hair Follicle Growth and Stem Cell Progeny Expansion

November 2022 in “Journal of Investigative Dermatology”

This study found that stimulating the olfactory receptor OR2A4/7 with cyclohexyl salicylate promoted human hair growth and increased progeny of hair follicle epithelial stem cells in an ex vivo setting.

Treatment With Cyclohexyl Salicylate, an Olfactory Receptor 2A4/7 Agonist, Promotes Human Hair Follicle Growth and Bulge Stem Cell Progeny Expansion

research 732 Treatment with cyclohexyl salicylate, an olfactory receptor 2A4/7 agonist, promotes human hair follicle growth and bulge stem cell progeny expansion

July 2022 in “Journal of Investigative Dermatology”

This study found that the cosmetic olfactory receptor agonist cyclohexyl salicylate may stimulate hair growth and expand stem cell progeny, suggesting potential as a cosmetic adjuvant for hair loss.

STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction, Hair Follicle Regeneration, and Wound Healing

research 219 STAT5 activation in the dermal papilla is important for hair follicle growth phase induction, hair follicle regeneration and wound healing

1 citations , August 2016 in “Journal of Investigative Dermatology”

This research reported that STAT5 activation in the dermal papilla plays a crucial role in triggering anagen entry during post-developmental hair follicle cycling.

Topical Odorant Application of the Specific Olfactory Receptor OR2AT4 Agonist, Sandalore, Improves Telogen Effluvium-Associated Parameters

research Topical odorant application of the specific olfactory receptor OR2AT4 agonist, Sandalore^®, improves telogen effluvium‐associated parameters

11 citations , July 2020 in “Journal of Cosmetic Dermatology”

This study found that a 1% Sandalore® solution reduced hair shedding and improved hair volume and anagen phase duration in women with telogen effluvium over 24 weeks, compared to placebo.

research Olfactory receptor OR2AT4 regulates human hair growth

82 citations , September 2018 in “Nature Communications”

This study found that stimulating the olfactory receptor OR2AT4 in human hair follicles with a synthetic sandalwood odorant promotes hair growth ex vivo by decreasing apoptosis and increasing IGF-1 production.

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community Sandalore experiment

18 upvotes 7 years ago

A user added sandalore to minoxidil for hair loss, observing some vellus hair growth and less scalp inflammation. Others tried sandalore with mixed results, discussing dosage and effectiveness compared to minoxidil and finasteride.

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