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research Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

57 citations , January 2013 in “International Journal of Medical Sciences”

This study reports that Lef1 plays a crucial role in promoting bulge stem cell differentiation towards hair fate by activating β-catenin and downstream signaling pathways during hair follicle development.

research Nuclear Factor I-C Regulates TGF-β-dependent Hair Follicle Cycling*

25 citations , August 2010 in “Journal of Biological Chemistry”

This study found that NFI-C plays a crucial role in the transition from the telogen to anagen phase of the hair follicle cycle, affecting hair growth initiation in mice.

research 1386 Trichodysplasia spinulosa small T antigen drives ectopic hair follicle development in adult transgenic mice

1 citations , April 2018 in “Journal of Investigative Dermatology”

The Trichodysplasia spinulosa virus protein can cause abnormal hair growth in mice.

research Distinct tooth regeneration systems deploy a conserved battery of genes

September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that zebrafish and stickleback fish use similar genetic programs for tooth regeneration, despite differences in their dental structures.

research Skin tumors with matrical differentiation: lessons from hair keratins, beta‐catenin and PHLDA‐1 expression

47 citations , February 2014 in “Journal of Cutaneous Pathology”

This study found that nuclear beta-catenin, LEF1, and PHLDA1 expression was conserved in matrical tumors, suggesting a shared tumorigenesis process involving Wnt pathway activation.

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community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Nuclear stack not working still

1 upvotes 8 months ago

A 20-year-old has been using topical minoxidil since 2021, oral finasteride since 2023, oral minoxidil for 6 months, and dutasteride for 2 months to combat hair loss but is still experiencing temple thinning. Suggestions include continuing medication, considering a future hair transplant, and taking monthly progress pictures.

community Nuclear topical fin formulation?

1 upvotes 1 year ago

The conversation discusses a hair loss treatment involving oral minoxidil, topical finasteride, and a custom topical formulation with minoxidil, cetirizine, finasteride, progesterone, and hydrocortisone. The user seeks advice on the effectiveness of these ingredients for diffuse thinning.

community Nuclear stack: 2.5mg dutasteride vs 0.5mg dutasteride + topical finasteride/dutasteride/spironolactone for male pattern baldness

in Research/Science 4 upvotes 1 year ago

The conversation discusses using 2.5mg dutasteride, 0.5mg dutasteride with topical treatments, and other combinations like oral minoxidil, RU58841, and microneedling for male pattern baldness. Users share experiences and suggest various treatment regimens, emphasizing the effectiveness of dutasteride and minoxidil.

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