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GlossaryGlucocorticoid Receptor (NR3C1)

regulates gene expression by binding to glucocorticoid hormones

The Glucocorticoid Receptor (GR) is a type of protein found inside cells that binds to glucocorticoids, which are a class of steroid hormones. When these hormones bind to the receptor, it can influence the expression of specific genes, thereby regulating processes like inflammation, immune response, and metabolism. This receptor is crucial in medical treatments for conditions like asthma, autoimmune diseases, and even certain types of hair loss, such as alopecia areata.

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research Recent Advances in the Molecular Mechanisms Causing Primary Generalized Glucocorticoid Resistance

15 citations, April 2016 in “Hormones”

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

research Chrousos Syndrome: From Molecular Pathogenesis to Therapeutic Management

47 citations, February 2015 in “European Journal of Clinical Investigation”

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

research Novel Insights Into the Molecular Mechanisms Underlying Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes

15 citations, July 2017 in “Hormones”

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

research Glucocorticoid Resistance Syndrome in Two Patients With Diverse Genotype

January 2025 in “JCEM Case Reports”

Diagnosing and managing Glucocorticoid Resistance Syndrome is complex due to genetic differences and varied symptoms.

research The Glucocorticoid Resistance Syndrome: Two Cases of a Novel Pathogenic Variant in the Glucocorticoid Receptor Gene

December 2023 in “JCEM case reports”

A new gene variant causes glucocorticoid resistance in a mother and son.

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