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Glossary Notch signaling

cell communication system regulating development and tissue maintenance

Notch signaling is a fundamental communication system used by cells to control various developmental processes and maintain tissue homeostasis. It involves interactions between neighboring cells through the Notch receptor and its ligands, leading to changes in gene expression that influence cell fate decisions, such as differentiation, proliferation, and apoptosis. This pathway is crucial in many biological contexts, including the development of hair follicles and the regulation of stem cells.

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research Melanoblasts' Proper Location and Timed Differentiation Depend on Notch/RBP-J Signaling in Postnatal Hair Follicles

70 citations , May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that Notch signaling is crucial for maintaining proper melanocyte distribution and preventing premature differentiation in the melanocyte lineage within hair follicles.

research The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development

16 citations , March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers observed that a noncanonical mechanism involving the γ-secretase-dependent, RBPj-independent Notch intracellular domain improves survival in Msx2-Cre mice by delaying hair follicle destruction and reducing disease severity.

research Hemidesmosomes and Notch signaling regulate epidermal differentiation via delamination

April 2026 in “Development”

This study found that loss of integrin-β4 or its ligand, laminin-α3β3ɣ2, in keratinocytes increases differentiation via delamination, and demonstrated a role for hemidesmosomes in epidermal differentiation through both mitotic and non-mitotic mechanisms, influenced by Notch signaling.

research RBPJ Mutations Identified in Two Families Affected by Adams-Oliver Syndrome

112 citations , August 2012 in “The American Journal of Human Genetics”

In this study, two unique mutations in the RBPJ gene were identified and linked to Adams-Oliver syndrome, confirming impaired DNA binding of mutated RBPJ as a factor in this rare genetic disorder.

research Accelerated Endothelial to Mesenchymal Transition Increased Fibrosis via Deleting Notch Signaling in Wound Vasculature

26 citations , December 2017 in “Journal of Investigative Dermatology”

This study found that the acceleration of endothelial to mesenchymal transition due to loss of Notch signaling led to delayed wound healing and increased scarring in skin wounds.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Freiburg, Baden-Württemberg, Germany

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