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Research

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research Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma

20 citations , February 2016 in “American Journal of Pathology”

This study indicates that the OVOL1-OVOL2 axis may play a significant role in hair follicle differentiation and growth, potentially serving as therapeutic targets for hair disorders like alopecia and in the tumorigenesis of pilomatricoma.

research LB1605 3D imaging of cleared ex vivo normal human skin, skin appendages and psoriasiform skin lesion using light-sheet microscopy

August 2018 in “Journal of Investigative Dermatology”

This study found that combining optical clearing methods with light-sheet fluorescence microscopy allows detailed 3D visualization of normal and pathological human skin biopsies, revealing differences in epidermal thickness and volume.

research A preliminary study of differentially expressed genes in expanded skin and normal skin: implications for adult skin regeneration

16 citations , January 2011 in “Archives of Dermatological Research”

This study identified 77 genes with significant expression changes in expanded human skin, suggesting possible mechanisms for skin regeneration during tissue expansion, including previously unreported genes like HOXA5, HOXB2, and AP1.

research CD99 Is Strongly Expressed in Basal Cells of the Normal Adult Epidermis and Some Subpopulations of Appendages: Comparison with Developing Fetal Skin

8 citations , August 2016 in “Journal of pathology and translational medicine”

This study found that CD99 is strongly expressed in the basal cells and hair follicles of normal adult and developing fetal skin, with expression patterns becoming similar after 20 weeks of gestation.

research Expression of retinoid-X receptors (-Æ,-a,-a) and retinoic acid receptors (-Æ,-a,-a) in normal human skin: an immunohistological evaluation

January 1997

This study found that RXR and RAR proteins were detectable in normal human skin, suggesting they may play a role in epidermal cell differentiation and hair and gland physiology.

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Community Join

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community So does oral minoxidil age your skin or not

43 upvotes 2 years ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community Testosterone in Reference Range Doesn't Cause Hair Loss

52 upvotes 2 years ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community Now that hair loss in mice is solved, can they move on to people?

709 upvotes 6 months ago

Hair loss treatments are being tested on mice, with methods like minoxidil and stem cell therapy showing promising results. However, human trials are still years away, leading to humorous frustration about mice benefiting first.

community Regenix hair treatment and my story

16 upvotes 3 weeks ago

Regenix hair treatment is ineffective and considered a marketing scam, with no noticeable improvement in hair thickness or fullness. Users suggest avoiding it and saving money.

community No fearmongering /just facts on yesterday someone posting on eye issues

in Finasteride/Dutasteride 33 upvotes 1 year ago

Finasteride and dutasteride may not significantly impact meibomian gland function since these glands do not rely on DHT. Some users report dry eyes and other side effects from finasteride, but these may be influenced by other factors or medications.

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Learn

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learn Scalp Micropigmentation

How long does scalp micropigmentation take to heal? Providers say the skin surface usually heals in about 7-14 days, and some say full healing and pigment settling take 4-6 weeks.
Is scalp micropigmentation a tattoo? Scalp micropigmentation is a specialized form of tattooing for hair loss.

learn Hair Transplant

How long does recovery take after a hair transplant? Recovery after a hair transplant typically takes 7 to 14 days for initial healing.

learn vitamin b2

What role does Vitamin B2 (Riboflavin) play in maintaining healthy hair follicles? Riboflavin (vitamin B2) is needed for normal cell energy metabolism, and severe deficiency can affect the skin. A 2019 review found no good evidence that extra B2 helps hair in people who are not deficient.

learn Vitamin D

Vitamin made in the skin from sunlight, also taken as a supplement

learn Folic acid

Is there a difference between taking folic acid supplements and using folic acid in topical hair products? Oral folic acid uses the body's normal absorption route and can correct a measured deficiency, but no published trial shows it treats hair loss; topical folic acid has no human evidence for hair growth, and no published human data show how much of it a plain shampoo or serum gets through the skin barrier.

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