August 2019 in “International journal of dermatology and venereology” The calcineurin/NFAT pathway plays a significant role in the development and growth of a type of skin cancer called cutaneous squamous cell carcinoma.
13 citations
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January 2021 in “Scientific Reports” Pannexin 3 helps skin and hair growth by controlling a protein called Epiprofin.
November 2025 in “Advanced Science” The study introduces a novel polyphenol–amino acid nanozyme (PEAs) that enhances H2O2 production to drive oxidative eustress, promoting hair regeneration. By combining epigallocatechin gallate (EGCG) and L-arginine (L-Arg), the nanozyme facilitates controlled H2O2 generation, which is crucial for activating hair follicles. In a mouse model of telogen effluvium, this controlled delivery of H2O2 upregulates Wnt/β-catenin and downregulates Ca2+/calcineurin/NFAT pathways, leading to significant follicle activation. This approach offers a non-pharmacological, safe, and effective strategy for treating alopecia by harnessing beneficial oxidative stress for tissue renewal.
40 citations
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March 2019 in “Nature Communications” CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.
27 citations
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February 2020 in “Journal of Cardiovascular Translational Research” Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.