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GlossaryNeuroendocrine Tumor

cancer arising from hormone-producing nerve cells

A Neuroendocrine Tumor (NET) is a type of cancer that arises from neuroendocrine cells, which are specialized cells that have traits of both nerve cells and hormone-producing cells. These tumors can occur in various parts of the body, including the gastrointestinal tract, pancreas, and lungs, and they can produce hormones that cause a range of symptoms depending on their location and the hormones they secrete.

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research Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice

14 citations, February 2022 in “The Journal of clinical investigation/The journal of clinical investigation”

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

research First-In-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

505 citations, December 2011 in “Journal of clinical oncology”

MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.

Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

research Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

1 citations, April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

research Disruption of Anthrax Toxin Receptor 1 in Pigs Leads to a Rare Disease Phenotype and Protection from Senecavirus A Infection

7 citations, March 2022 in “Scientific reports”

Removing anthrax toxin receptor 1 in pigs prevents Senecavirus A infection and causes a rare disease similar to GAPO syndrome.

research 5-Alpha Reductase Inhibitors in Prostate Cancer: From Clinical Trials to Clinical Practice

7 citations, May 2013 in “European Urology”

5-Alpha reductase inhibitors may prevent prostate cancer but are not widely used due to concerns about trial relevance and potential risks, and more research is needed to confirm long-term benefits.

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community Why is Kevin Mann (Haircafe) Hated?

in Chat 62 upvotes 1 year ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community how does my progress look 18M 3 months on fin 1mg daily

in Progress Pictures 277 upvotes 10 months ago

An 18-year-old male's successful hair regrowth after three months of using finasteride 1mg daily. He reported no side effects and other users expressed admiration and curiosity about his results.

community Fluridil vs Breezula?

in Treatment 15 upvotes 3 years ago

Comparing two upcoming topical hair loss treatments, Fluridil and Breezula, to determine which is most effective for treating hair loss, taking into consideration factors such as price, side effects, potential for hair growth, convenience of application, smell, greasiness, and styling after use.

community Possible explanation of why Dutasteride seems to be worse for some people’s hair.

in Treatment 47 upvotes 1 year ago

The conclusion of the conversation is that some individuals may experience a condition called reactionary hypergonadism when taking dutasteride for hair loss. This condition can lead to an increase in testosterone levels, which may worsen hair loss instead of improving it.

community I’ve been shaving my head for 15 years. Is there anything out there that can truly regrow hair?

in Hair Systems 1 year ago

A user who has been shaving his head for 15 years looking for potential treatments to regrow hair; the replies range from advice to try out medications such as finasteride and minoxidil, to suggestions of changing up his look with facial hair or hobbies.