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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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research Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients
Antiandrogens might help prevent or treat COVID-19 by blocking the virus's entry into cells.
research Abiraterone and Spironolactone in Prostate Cancer: A Combination to Avoid
Don't combine abiraterone and spironolactone for prostate cancer treatment as it may worsen the disease.
research HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond
Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.
research Low-Intensity Ultrasound as a Potential Intervention Strategy to Protect Human Scalp Hair Follicles from Taxane-Induced Toxicity
This study examines the use of low-intensity ultrasound (LIUS) as a protective measure against paclitaxel-induced alopecia (PIA) in human scalp hair follicles. Paclitaxel, a taxane used in cancer treatment, often causes significant hair loss. The pilot study involved organ-cultured human anagen VI scalp hair follicles treated with paclitaxel and exposed to LIUS. Results indicated that LIUS significantly reduced apoptosis, mitotic disruption, and DNA damage in hair matrix keratinocytes, restoring their proliferative activity. Despite the study's limitation due to the small number of hair follicles and donors, the findings suggest that LIUS could be a safe, cost-effective method to protect scalp hair follicles from chemotherapy-induced damage, potentially reducing PIA severity. Further research is needed to confirm these effects and explore combining LIUS with scalp cooling for enhanced protection.
research SRD5A2 and Emerging Therapies in Androgen-Driven Disorders
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5 / 7 resultscommunity Ketoconazole mesotherapy plausible?
The conversation discusses using ketoconazole, an anti-androgen, for hair loss and whether mesotherapy with dermarolling could enhance its absorption into the scalp. The user questions if the typical 2% ketoconazole shampoo dose would be effective when used after dermarolling to target androgen receptors in the scalp.
community Can finasteride affect on your muscle and other things?
The conversation discusses using finasteride topically for hair loss and concerns about potential side effects like feminization and impact on muscle growth. One person shared their experience with finasteride, indicating it increased testosterone and did not prevent them from gaining muscle or strength.
community I'm very skeptical about pyrilutamide
Pyrilutamide's effectiveness is questioned due to overstated claims and previous trial ineffectiveness, with some users opting for finasteride instead. Despite skepticism, some consider adding pyrilutamide to their regimen alongside treatments like bicalutamide.
community Dermatologist told me to quit fin after turning 40
A dermatologist advised a patient to stop taking finasteride (fin) after turning 40 due to potential risk of aggressive prostate cancer. The patient and others in the conversation debated this advice, discussing the relationship between finasteride, prostate cancer, and hair loss, and considering alternatives like topical finasteride.
community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?
Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.