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GlossaryMEK inhibitors (MEKis)

block enzymes involved in cell growth signaling pathways

MEK inhibitors, also known as MEKis or MEK1/2 inhibitors, are a class of drugs that block the activity of the MEK enzymes (MEK1 and MEK2), which are part of the MAPK/ERK signaling pathway. This pathway is crucial for cell division and survival, and its dysregulation is often implicated in various cancers. By inhibiting MEK, these drugs can help to slow down or stop the growth of cancer cells.

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research Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails

179 citations, October 2018 in “American Journal of Clinical Dermatology”

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

research Dermatologic Adverse Events from Cancer Treatments

2 citations, October 2018 in “Springer eBooks”

Cancer treatments can cause skin-related side effects that may affect patient quality of life and require changes in treatment.

research When Bugs and Drugs Conspire: Driving Acneiform Skin Toxicity

1 citations, February 2020 in “The Journal of clinical investigation/The journal of clinical investigation”

Certain cancer drugs interact with skin bacteria to cause acne-like rashes.

research Cutaneous Side Effects of Modern Targeted Therapy and Immunotherapy in Patients with Dermatological Malignancies

June 2023 in “Cancers”

Modern skin cancer treatments can cause skin side effects and hair loss, affecting patients' quality of life.

research IL-36γ Drives Skin Toxicity Induced by EGFR/MEK Inhibition and Commensal Cutibacterium Acnes

32 citations, December 2019 in “The Journal of clinical investigation/The journal of clinical investigation”

A protein called IL-36γ causes skin side effects from certain cancer treatments when combined with a common skin bacteria.

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community 6.5 month progress with Dustasteride, Topical minoxidil and microneedling.

in Progress Pictures 54 upvotes 1 year ago

Progress made in treating hair loss using Dustasteride, topical Minoxidil and microneedling.

community 148 Days Minoxidil+Finasteride Topical, Keto Shampo 2x Weekly

in Progress Pictures 53 upvotes 1 year ago

Treating hair loss with a combination of topical minoxidil and finasteride, as well as keto shampoo twice weekly; other treatments such as microneedling and oral finasteride were discussed but the user is hesitant due to potential scarring. Additionally, another user suggested switching to oral minoxidil for further gains.

community New study shows that microneedling is an ineffective hair loss treatment

in Research/Science 1 year ago

The effectiveness of microneedling as a hair loss treatment, with evidence from studies and anecdotal accounts from other users. It is suggested that combining microneedling with minoxidil or finasteride may be more effective than using microneedling alone, although some people have had success using only microneedling.

community Tell me I should be grateful, I’m trying not to shave it off. I’ve had about 2500 graft’s transplanted but I hate seeing my scalp.

in Is this regrowth? 101 upvotes 1 year ago

A user who had two hair transplants and is still concerned about their crown area, despite other people reassuring them that it looks normal. The advice given was to use Minoxidil, Finasteride, SMP, and to consider speaking with a therapist.

community Help in Germany to get recommended medicine

in Finasteride/Dutasteride 5 upvotes 1 month ago

A user in Germany is seeking advice on obtaining Dutasteride, Minoxidil, and Biotin for hair treatment before a hair transplant. They face difficulties getting prescriptions and are concerned about delays due to required exams.

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