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Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

223 citations, December 2010 in “The Journal of Sexual Medicine”

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

research Finasteride Use and Acute Pancreatitis in Taiwan

10 citations, January 2015 in “The Journal of Clinical Pharmacology”

No clear link between finasteride use and acute pancreatitis risk.

A Retrospective Study of Clinical Outcomes of Alpha-Blocker or Finasteride Monotherapy Followed by Combination Therapy: Determination of the Period of Combination Therapy of Alpha-Blocker and Finasteride

research A Retrospective Study of Clinical Outcomes of Alpha-Blocker or Finasteride Monotherapy Followed by Combination Therapy: Determination of the Period of Combination Therapy of Alpha-Blocker and Finasteride

3 citations, April 2013 in “International Journal of Clinical Practice”

Combination therapy for 9+ months maintains symptom improvements after stopping alpha-blockers or finasteride.

research A Review of the Treatment of Male Pattern Hair Loss

53 citations, February 2020 in “Expert Opinion on Pharmacotherapy”

Finasteride and minoxidil work best together for hair loss.

research Androgen Treatment of Postmenopausal Women

28 citations, May 2013 in “The Journal of Steroid Biochemistry and Molecular Biology”

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

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community day 107 of kx826 .5% . 1+ years on topical minoxidil.

in Progress Pictures 15 upvotes 1 month ago

The user has been using topical minoxidil for over a year and added kx826/pyrilutamide to improve hair growth, avoiding finasteride due to side effects like lowered libido and panic attacks. They report positive results with reduced shedding and healthier hair, particularly in areas previously unresponsive to minoxidil.

community 1.25mg of Fin and 5% topical minoxidil once a day. 8 months progress. Diffuse thinning

in Progress Pictures 458 upvotes 2 years ago

This user experienced improvements in their hair density and texture through the use of finasteride (1.25mg) and minoxidil (5%) applied topically once a day over 8 months, with no reported side effects other than slightly lowered libido.

community My 12-step program for hair-regrowth

in Treatment 3 upvotes 1 year ago

A 28-year-old male shares his 12-step hair regrowth routine, including finasteride, minoxidil, RU58841, LLLT, dermarolling, various shampoos, supplements, and a healthy diet. He seeks advice on microneedling frequency and mentions experiencing lowered libido and occasional scalp inflammation.

community Finasteride + Cialis together long term?

in Treatment 3 upvotes 4 months ago

The user has been on 1mg finasteride for a year, experiencing low libido and moderate erectile issues. They are considering using Cialis daily with finasteride long term to address these side effects.

community 42M 5 months (topical fin, oral min)

in Progress Pictures 35 upvotes 1 year ago

A 42-year-old man is using topical finasteride, oral minoxidil, microneedling, ketoconazole shampoo, and various oils for hair loss treatment and is happy with the improvements after 5 months. He experienced mild side effects from finasteride, including temporary testicular pain and changes in libido, but no side effects from minoxidil.

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