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research Silicones as conditioning agents in shampoos

5 citations , January 1992

This study found that dimethicone with high molecular weight improved hair surface characteristics, while dimethicone copolyol and amodimethicone enhanced manageability by reducing friction or aiding styling on damaged hair.

research Optimized skin optical clearing for optical coherence tomography monitoring of encapsulated drug delivery through the hair follicles

19 citations , January 2020 in “Journal of Biophotonics”

This study found that using a PEG-400/oleic acid mixture as an optical clearing agent enhanced the detection depth of particles in skin without causing dehydration, based on tests in rats and further testing in vivo.

research Improvement of Hair Damage by Lipophilic Vitamin C (Ascorbyl Tetraisopalmitate)

September 2018 in “Journal of Society of Cosmetic Chemists of Japan”

This study found that applying a solution containing oil-soluble vitamin C to damaged hair improved hair cuticle condition and water repellency, suggesting a new cosmetic function beyond its known skin whitening effects.

research Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

42 citations , January 2021 in “Journal of Clinical Medicine”

This review discusses advancements in the use of microneedle arrays and nanoparticles for transdermal delivery of therapeutics, noting challenges in overcoming the skin barrier and summarizing recent clinical trial achievements in areas like cancer therapy and gene therapy.

research Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones

75 citations , August 2006 in “International Journal of Pharmaceutics”

The eucalyptus oil system improved skin delivery of hormones, but safety concerns remain.

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community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 7 months ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

23 upvotes 1 year ago

Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

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