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research Decision Letter: Human Biallelic MFN2 Mutations Induce Mitochondrial Dysfunction, Upper Body Adipose Hyperplasia, and Suppression of Leptin Expression

January 2017

MFN2 mutations cause mitochondrial problems, unusual fat distribution, and low leptin despite high body fat.

Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan

research Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan

926 citations , June 2010 in “BMC Medicine”

Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.

research Polycystic Ovary Syndrome and Infertility: An Update

26 citations , July 2021 in “International journal of adolescent medicine and health”

New treatments for PCOS are improving fertility and managing symptoms better.

research The Effect of a Very-Low-Calorie Diet Versus a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome: A Randomised Controlled Trial

20 citations , September 2023 in “Nutrients”

A very-low-calorie diet led to more weight loss and health improvements in obese women with PCOS than a moderate energy deficit diet.

research A Guide to Studying Human Dermal Adipocytes In Situ

21 citations , March 2018 in “Experimental Dermatology”

The guide explains how to study human skin fat cells and their tissue, aiming to improve research and medical treatments.

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Community Join

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community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 43 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community Minoxidil + Gym + Cutting. Is it bad?

in Minoxidil 39 upvotes 2 years ago

A user is concerned about weight loss stagnation while using minoxidil and finasteride during a calorie-cutting diet. Responses suggest water retention or a weight loss plateau as possible causes.

community Got my Oleic fatty acid they used in Korean study. Fuck you mice!

in Research/Science 217 upvotes 2 days ago

Oleic acid and microneedling are being explored for hair regrowth, but results are mixed. Addressing DHT and fibrosis is crucial, with treatments like finasteride, minoxidil, and scalp massage also discussed.

community FtM: "Aggressive Regemin - Recovery From Norwood-6.5" Minoxodil/Estradiol valerate/Spironolactone. (What will happen in the worst case if CIS male go this way for a year?)

in Progress Pictures 55 upvotes 4 years ago

User "Ant1pal" shares progress pictures of hair regrowth using Minoxidil, Estradiol valerate, and Spironolactone. Users discuss potential side effects and the possibility of localizing estrogen to hair follicles for better treatment.

community The Big Fat Layer II

in Research/Science 26 upvotes 5 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

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