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The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

Dutasteride and finasteride have similar risk profiles despite Dutasteride blocking more types of 5AR in the brain. Some users report no mood issues with either drug, and it is suggested that Dutasteride's larger molecular size may limit its ability to cross the blood-brain barrier.

The user is experimenting with a homemade topical dutasteride formulation to reduce hair loss while minimizing systemic absorption, using MCT oil, almond oil, vitamin E, tea tree oil, and lavender oil. They are monitoring hair growth and side effects, particularly focusing on sexual health, and are open to feedback on their approach.