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    Glossary Lignans

    plant-derived compounds with estrogen-like effects

    Lignans are a group of chemical compounds found in plants, particularly in seeds like flaxseed, as well as in grains, vegetables, and fruits. They are phytoestrogens, meaning they can mimic or modulate the action of estrogen in the body, and have been studied for their potential health benefits, including antioxidant properties and possible roles in reducing the risk of certain cancers and cardiovascular diseases.

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    1. Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances Pharmacological Research · 2019 · 112 citations
    2. Nature-derived lignan compound VB-1 exerts hair growth-promoting effects by augmenting Wnt/β-catenin signaling in human dermal papilla cells PeerJ · 2018 · 17 citations
    3. Peer Review #1 of "Nature-derived lignan compound VB-1 exerts hair growth-promoting effects by augmenting Wnt/β-catenin signaling in human dermal papilla cells (v0.1)" 2018
    4. FEMALE BREAST CANCER PROTECTION USING PHYTOESTROGEN LIGNANS FROM FLAXSEED International Journal of Pharmacology · 2026
    5. Anti-BPH lignans from <i>Urtica triangularis</i> subsp. <i>pinnatifida</i> (Hand.-Mazz.) C.J.Chen Natural product research · 2023
    6. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004 · 144 citations
    7. A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005 · 91 citations
    8. Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-β Signaling during the Inflammatory Response to Cutaneous Injury Endocrinology · 2012 · 56 citations
    9. Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice Experimental Dermatology · 2013 · 22 citations
    10. A Girl with a Novel Splice Site Mutation in <i>VDR</i> Supports the Role of a Ligand-Independent VDR Function on Hair Cycling Hormone Research in Paediatrics · 2006 · 21 citations
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    1. Pyrilutamide from Ligand Chem in the UK Reddit · 4 Jan 2023

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