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    Glossary Lignans

    plant-derived compounds with estrogen-like effects

    Lignans are a group of chemical compounds found in plants, particularly in seeds like flaxseed, as well as in grains, vegetables, and fruits. They are phytoestrogens, meaning they can mimic or modulate the action of estrogen in the body, and have been studied for their potential health benefits, including antioxidant properties and possible roles in reducing the risk of certain cancers and cardiovascular diseases.

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    Research 30 of 1000+

    1. Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances Pharmacological Research · 2019 · 112 citations
    2. Nature-derived lignan compound VB-1 exerts hair growth-promoting effects by augmenting Wnt/β-catenin signaling in human dermal papilla cells PeerJ · 2018 · 17 citations
    3. Peer Review #1 of "Nature-derived lignan compound VB-1 exerts hair growth-promoting effects by augmenting Wnt/β-catenin signaling in human dermal papilla cells (v0.1)" 2018
    4. FEMALE BREAST CANCER PROTECTION USING PHYTOESTROGEN LIGNANS FROM FLAXSEED International Journal of Pharmacology · 2026
    5. Anti-BPH lignans from <i>Urtica triangularis</i> subsp. <i>pinnatifida</i> (Hand.-Mazz.) C.J.Chen Natural product research · 2023
    6. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004 · 144 citations
    7. A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005 · 91 citations
    8. Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-β Signaling during the Inflammatory Response to Cutaneous Injury Endocrinology · 2012 · 56 citations
    9. Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice Experimental Dermatology · 2013 · 22 citations
    10. A Girl with a Novel Splice Site Mutation in <i>VDR</i> Supports the Role of a Ligand-Independent VDR Function on Hair Cycling Hormone Research in Paediatrics · 2006 · 21 citations
    11. Presence of a Deletion Mutation (c.716delA) in the Ligand Binding Domain of the Vitamin D Receptor in an Indian Patient with Vitamin D-Dependent Rickets Type II Calcified tissue international · 2009 · 18 citations
    12. Ligand‐Independent Actions of the Vitamin D Receptor: More Questions Than Answers JBMR plus · 2021 · 11 citations
    13. Ligand‐independent Regulation of the hairless Promoter by Vitamin D Receptor<sup>†</sup> Photochemistry and photobiology · 2008 · 10 citations
    14. High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase Acta Crystallographica Section D-biological Crystallography · 2014 · 5 citations
    15. Ligand Based 3D-QSAR Study on a Series of Steroidal Human 5&#945;-Reductase Inhibitors Letters in Drug Design & Discovery · 2010 · 3 citations
    16. Fabrication of carboxymethyl cellulose/hyaluronic acid/polyvinylpyrrolidone composite pastes incorporation of minoxidil-loaded ferulic acid-derived lignin nanoparticles and valproic acid for treatment of androgenetic alopecia International Journal of Biological Macromolecules · 2023 · 1 citations
    17. Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators Acta crystallographica · 2008 · 1 citations
    18. Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin International Journal of Molecular Sciences · 2025
    19. Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin 2024
    20. Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats Cells · 2023
    21. Ligand-Independent Actions of Vitamin D Receptor Elsevier eBooks · 2017
    22. 1448 Ligand-dependent Wnt signaling attenuates mechanotransduction and protects against wound occlusion-mediated abolishment of hair follicle regeneration Journal of Investigative Dermatology · 2023
    23. Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation Development · 2012 · 207 citations
    24. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012 · 170 citations
    25. Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis Journal of Investigative Dermatology · 2007 · 78 citations
    26. Localisation of members of the notch system and the differentiation of vibrissa hair follicles: Receptors, ligands, and fringe modulators Developmental dynamics · 2000 · 62 citations
    27. Two-ligand priming mechanism for potentiated phosphoinositide synthesis is an evolutionarily conserved feature of Sec14-like phosphatidylinositol and phosphatidylcholine exchange proteins Molecular biology of the cell · 2016 · 25 citations
    28. <i>In Vitro</i>and<i>in Vivo</i>Structure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring Endocrinology · 2005 · 20 citations
    29. CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth Biochemical Journal · 2016 · 15 citations
    30. Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching 2015 · 7 citations