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GlossaryLichen Simplex Chronicus

chronic skin condition causing thickened, itchy patches from repeated scratching

Lichen Simplex Chronicus (LSC), also known as Neurodermatitis, is a skin condition characterized by chronic itching and scratching, leading to thickened, leathery patches of skin. It often results from a cycle where an initial itch causes scratching, which then exacerbates the itch, creating a persistent problem. This condition can be triggered by stress, dry skin, or other underlying skin disorders.

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research Lichen Simplex Chronicus on the Scalp: Broom Fibers on Dermoscopy; Gear Wheel Sign and Hamburger Sign on Histopathology

4 citations, January 2020 in “Indian dermatology online journal”

Lichen simplex chronicus on the scalp can be diagnosed by specific hair and skin signs and treated with corticosteroids and therapy.

research Lichen Simplex Chronicus Positive for C5b-9/MAC, IgD, and C3c Due to Recurrent Bacterial Hair Follicular Unit Infection

October 2020 in “Our Dermatology Online”

Chronic bacterial infections of hair follicles can cause ongoing skin inflammation.

research Cicatricial Alopecia with Particular Trichoscopic and Histopathological Features

November 2018 in “Skin appendage disorders”

The document concludes that a woman has both Frontal Fibrosing Alopecia and Lichen Simplex Chronicus, a previously unreported combination of conditions.

To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

research To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

23 citations, May 2016 in “American Journal of Pathology”

The research suggests that a specific skin gene can be controlled by signals within and between cells and is wrongly activated in certain skin diseases.

research A Case of Neurodermatitis Circumscripta of Scalp Presenting as Patchy Alopecia

11 citations, January 2013 in “International Journal of Trichology”

Emotional factors are crucial in treating and preventing scalp neurodermatitis and hair loss.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community C’est terrible - at my wits end

in Female 441 upvotes 1 year ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

community After Years of Treatment, I'm Shaving my Head and Giving Up

in Shaved/buzzed 119 upvotes 1 week ago

After years of using dutasteride and oral minoxidil without success, the individual decided to shave their head and stop treatment. They considered scalp micropigmentation and hair systems but ultimately accepted their hair loss.

community My result with 5month min+micro1m+tretinoin0.0025+nizoral

in Progress Pictures 103 upvotes 11 months ago

The conversation discusses hair loss treatment results after 5 months using Minoxidil, microneedling with a 1mm length every 5 days, Tretinoin (0.0025%), and Nizoral. The user noticed an increase in hair density.

community Is hair thinning or loss associated with pain?

in Research/Science 6 upvotes 1 year ago

Hair thinning/loss associated with burning scalp pain. Finasteride helped relieve "DHT itch" for one person.

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