36 citations,
December 2021 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Two drugs, ritlecitinib and brepocitinib, improved scalp hair loss condition markers.
176 citations,
August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.
27 citations,
March 2018 in “Allergy and asthma proceedings” People with alopecia areata often have higher rates of allergies and autoimmune diseases.
This study analyzed the effects of ritlecitinib, a JAK3/TEC family kinase inhibitor, on alopecia areata (AA) subtypes in a phase 2a trial with 142 participants. Ritlecitinib treatment over 12 and 24 weeks downregulated Type I and II immunity-related genes and upregulated hair keratin genes, with a stronger effect in patchy-type AA (AAP) compared to alopecia totalis/universalis (AT/AU). Changes in gene and serum protein levels correlated with clinical hair regrowth, suggesting that early molecular responses could predict clinical outcomes. The study supports ritlecitinib's role in modulating immune response and promoting hair regrowth, particularly in AAP, and highlights the potential of baseline gene expression profiles to predict therapeutic responses. Despite limitations, the findings indicate that ritlecitinib effectively targets key immune and hair structural genes, reducing inflammation and promoting hair regrowth in AA patients.
52 citations,
March 2010 in “British Journal of Dermatology” Alopecia areata shows a unique type 1 interferon signature, suggesting potential treatment by targeting this pathway.