3 citations
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July 1992 in “Clinics in Dermatology” Vitamin D helps regulate calcium levels in the body.
107 citations
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March 2014 in “BoneKEy Reports” Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.
82 citations
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April 1981 in “Clinical endocrinology” A girl with rickets and hair loss was found to have a rare condition where her body didn't respond to vitamin D treatment.
January 2019 in “Columbia Academic Commons (Columbia University)” The study focused on the structural analysis of TRPV3 and TRPV6, two members of the vanilloid subfamily of transient receptor potential (TRP) channels. TRPV6, involved in intestinal calcium absorption, was analyzed using cryo-electron microscopy to reveal its open and closed states, showing that its transition involves the formation of π-helices that widen the pore. TRPV6 is regulated by calmodulin (CaM), which binds to the channel and blocks it to prevent calcium overload. TRPV3, a heat-activated channel expressed in keratinocytes, was studied in both closed and open states, revealing structural changes that suggest a model for its regulation by 2-APB. These findings provided insights into the regulatory and gating mechanisms of these channels, contributing to the understanding of their physiological roles.
1 citations
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May 2019 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism” Intravenous calcium therapy is a safe and effective treatment for a rare type of rickets.