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Glossary Inner Root Sheath

layer of cells supporting and shaping the growing hair shaft

The Inner Root Sheath (IRS) is a layer of cells that surrounds and supports the growing hair shaft within the hair follicle. It plays a crucial role in shaping the hair and guiding it as it emerges from the scalp. The IRS is composed of three distinct layers: Henle's layer, Huxley's layer, and the cuticle of the inner root sheath, each contributing to the structural integrity and function of the hair follicle.

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Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia

research Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia

6 citations , December 2018 in “The American Journal of Dermatopathology”

This study found that the presence of premature desquamation of the inner root sheath in noninflamed hair follicles is a relatively specific marker for diagnosing central centrifugal cicatricial alopecia.

research Four murine monoclonal antibodies specific for the inner root sheath in the human hair follicle

1 citations , January 1989

This study produced and characterized four new monoclonal antibodies that specifically recognize differentiation antigens in human hair follicle and epidermal structures.

research 889 Trpv3 gain-of-function mutation impairs differentiation of hair follicle inner root sheath

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, the researchers introduced a mutation in mice to mimic Olmsted syndrome and found that the mutation caused hair loss due to impaired keratinocyte differentiation and depletion of hair follicle stem cells.

research Vesicle Formation and Follicular Root Sheath Separation in Mice Homozygous for Deleterious Alleles at the Balding (bal) Locus

38 citations , September 1997 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identified histologic lesions and a defect in adhesion molecules causing hair loss in mice with the bal mutation, linked to a mutation in the desmoglein 3 gene.

research Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans

38 citations , October 2001 in “British Journal of Dermatology”

This study identified a new keratin, K6irs, as a potential histological marker for the inner root sheath of hair follicles in mice and humans, and as a candidate gene for hereditary hair defects.

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Why is minoxidil the “regrowth stimulant” and finasteride “the maintenance”, when official studies show more growth on finasteride ?

in Research/Science 46 upvotes 6 months ago

Finasteride is more effective for long-term hair maintenance by addressing the root cause of hair loss, while minoxidil acts as a growth stimulant with faster visible results. Combining both treatments is optimal, with oral minoxidil often showing better results for some individuals.

community My understanding of how androgenetic alopecia works (plus FIN and DUT)

18 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

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