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    Glossary Inner Root Sheath

    layer of cells supporting and shaping the growing hair shaft

    The Inner Root Sheath (IRS) is a layer of cells that surrounds and supports the growing hair shaft within the hair follicle. It plays a crucial role in shaping the hair and guiding it as it emerges from the scalp. The IRS is composed of three distinct layers: Henle's layer, Huxley's layer, and the cuticle of the inner root sheath, each contributing to the structural integrity and function of the hair follicle.

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    Research 10 of 1000+

    1. Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia The American Journal of Dermatopathology · 2018 · 6 citations
    2. Four murine monoclonal antibodies specific for the inner root sheath in the human hair follicle 1989 · 1 citations
    3. 889 Trpv3 gain-of-function mutation impairs differentiation of hair follicle inner root sheath 2019
    4. Vesicle Formation and Follicular Root Sheath Separation in Mice Homozygous for Deleterious Alleles at the Balding (bal) Locus 1997 · 38 citations
    5. Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans British Journal of Dermatology · 2001 · 38 citations
    6. LB1019 The early region of trichodysplasia spinulosa polyomavirus drives proliferation, altered differentiation, and ectopic expression of hair follicle differentiation markers in interfollicular tail epidermis 2022
    7. Cytokeratins as Markers of Follicular Differentiation American Journal of Dermatopathology · 2001 · 121 citations
    8. LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis Scientific Reports · 2022 · 8 citations
    9. The cDNA-deduced amino acid sequence for trichohyalin, a differentiation marker in the hair follicle, contains a 23 amino acid repeat. 1990 · 39 citations
    10. K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1 Journal of Investigative Dermatology · 2003 · 130 citations
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    Community 1 of 2

    1. Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp Reddit · 19 May 2023
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