Four Murine Monoclonal Antibodies Specific for the Inner Root Sheath in the Human Hair Follicle
January 1989
TLDR Four antibodies were developed to help study hair follicle cell differentiation.
The study produced four murine monoclonal antibodies (MAB) specific to antigens (AG) in the inner root sheath (IRS) of the human hair follicle. These antibodies were developed using human plantar stratum corneum and characterized through histological and immunochemical methods. Three of the MABs recognized antigens also present in the stratum granulosum of the epidermis, while the G20-21 MAB was specific to the IRS cells. The research highlighted the potential of these MABs as new differentiation markers, providing insights into the differentiation pathways of epidermal and IRS cells.
