130 citations
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April 2003 in “Journal of Investigative Dermatology” This study reports the cloning and expression details of two new human type II keratins, K6irs3 and K6irs4, in the hair follicle's inner root sheath, suggesting a distinct functional role related to hair structure.
86 citations
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May 2002 in “Journal of Investigative Dermatology” This study characterized a new human keratin, hK6irs1, specifically found in the inner root sheath of hair follicles, which suggests its role in the structural integrity and guidance of growing hair shafts.
44 citations
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August 1990 in “PubMed” This study provides evidence for K1 and K10 derivatives' presence in the inner root sheath and hair cuticle, suggesting that these hair follicle parts may follow familiar keratinization principles.
22 citations
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June 2008 in “Experimental Dermatology” This study found that heparanase is primarily located in the inner root sheath of human hair follicles during the anagen phase, and inhibiting it in cultured hair follicles induces a catagen-like process.
59 citations
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August 1981 in “PubMed” This study describes trichilemmal keratinization as a distinct process of hair follicle keratinization that occurs in specific areas of the outer root sheath, illustrated using electron microscopy on dog hair.