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Dimethyl Fumarate Ameliorates Delayed Wound Healing Due to IL-36Ra Deficiency Through Inhibition of NET Formation and Oxidative Stress

research 1495 Dimethyl fumarate ameliorates delayed wound healing due to IL-36Ra deficiency through inhibition of NET formation and oxidative stress

April 2023 in “Journal of Investigative Dermatology”

This study found that dimethyl fumarate improved delayed wound healing in Il36rn-/- mice by reducing neutrophil extracellular trap formation and oxidative stress.

research Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

53 citations , July 2009 in “Cancer Research”

In this mouse study, the researchers found that the monoclonal antibody ME1 causes hair follicle inflammation by up-regulating TNFα, which can be reduced by TNFα and interleukin-1 inhibitors.

research FOLLICULAR LIPOSOMAL DELIVERY SYSTEMS

55 citations , January 2002 in “Journal of liposome research”

This research explores developing liposomal formulations to enhance the delivery of difficult-to-absorb agents directly to hair follicles and sebaceous glands, with minoxidil and plasmid DNA as study molecules.

research IL-1 alpha inhibits human hair follicle growth and hair fiber production in whole-organ cultures.

30 citations , August 1993 in “PubMed”

This study found that IL-1 alpha inhibits the growth of cultured human hair follicles and hair fibers, suggesting a potential role in inflammatory hair loss conditions like alopecia areata.

research The AhR pathway is dysregulated in alopecia areata

2 citations , March 2025 in “Journal of Translational Autoimmunity”

This study reports that AhR pathway expression is significantly reduced in lymphocytes of alopecia areata patients, suggesting its potential as a diagnostic marker and therapeutic target.

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Community Join

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Finasteride alternative close to fda approval in the US

60 upvotes 4 months ago

Breezula, a topical treatment, is anticipated to be available in the US by mid-2027 as a potential alternative to finasteride with fewer systemic side effects. There is ongoing debate about its effectiveness and some users report similar side effects to finasteride.

community Latest study on RU58841 done 19. August 2026.

25 upvotes 4 weeks ago

RU58841 can be absorbed systemically after topical application, but the study did not find immediate hormonal disruption. The study highlights the need for more research on long-term safety and effects of RU58841, as well as the importance of quality control in products from the grey market.

community Before & after for 3 months of minoxidil & 6 months of finasteride/minoxodil/tretinoin

658 upvotes 1 year ago

A 36-year-old experienced significant hair regrowth using minoxidil, finasteride, and tretinoin with minimal side effects. He plans to continue the treatment, hoping for more targeted solutions in the future.

community Creatine Doesn’t Cause Hair Loss: Stop the BS

137 upvotes 11 months ago

Creatine does not cause hair loss, despite many users reporting personal experiences of hair shedding. Scientific evidence shows no link between creatine and increased hair loss or hormone changes.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Experts

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74
Hair Loss Specialist
Will Quaye
Crawley, England, United Kingdom

Clinics

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Will Quaye