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research Dihydromyricetin attenuates fibrosis-associated features of hypertrophic scar with accompanying changes in PI3K/AKT/mTOR-related signaling

August 2026 in “Frontiers in Pharmacology”

This study found that dihydromyricetin may reduce fibrosis features in hypertrophic scars by affecting PI3K/AKT/mTOR signaling, but further research is needed to confirm causality.

research Fibroblasts and endothelial cells interplay drives hypertrophic scar formation: Insights from in vitro and in vivo models

21 citations , December 2023 in “Bioengineering & Translational Medicine”

This study found that crosstalk between fibroblasts and endothelial cells significantly contributes to hypertrophic scar formation by enhancing fibroblast activity through cytokine secretion, with pathway analyses suggesting molecular targets for potential therapeutic interventions.

research Self-Organizing 3D Dermal Papilla Cell Spheroids Yield Therapeutic Extracellular Vesicles that Target Hypertrophic Scar Regression via the miR-26a-5p/CCNE2 Axis

July 2025 in “Burns & Trauma”

In this study, researchers developed a new SFL-3D system to produce extracellular vesicles from rejuvenated dermal papilla cell spheroids, which demonstrated significant antifibrotic effects in reducing hypertrophic scarring, highlighting their potential for precision-targeted scar management.

Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Regeneration After Facial Nerve Injury

research Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury

6 citations , February 2022 in “The journal of neuroscience/The Journal of neuroscience”

This study observed that deleting PTEN in mouse facial motoneurons enhanced peripheral axon regeneration but also led to physiological changes and potential hyperplasia in older mice.

research A regulatory perspective on pharmacokinetic/pharmacodynamic modelling

18 citations , June 1999 in “Statistical Methods in Medical Research”

This paper reviews the role of pharmacokinetic/pharmacodynamic modeling in drug development, emphasizing its application for drug dosing guidance, safety resolution, and therapeutic monitoring improvement, without presenting new clinical results.

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community Just to show you the superiority of dutasteride over finasteride (it's huge)

in Research/Science 58 upvotes 2 years ago

Dutasteride is shown to be significantly more effective than finasteride for treating male androgenic alopecia. Users discuss the difficulty of obtaining dutasteride in some countries and share personal experiences with its effectiveness and side effects.

community Hair stack cost in Canada without insurance after a year

2 upvotes 4 weeks ago

A user shared their experience with hair loss treatments, spending $353 CAD annually on minoxidil and finasteride, and recommended consulting a dermatologist for accurate diagnosis. Another user mentioned that insurance might cover certain medications like finasteride 5mg and dutasteride when prescribed for prostate issues.

community Male pattern baldness is not cosmetic.

224 upvotes 9 months ago

Male pattern baldness is linked to health risks and should be treated medically. Finasteride is effective and should be insurance-covered.

community What's "wrong" with oral minoxidil, exactly?

in Minoxidil 173 upvotes 1 year ago

Oral minoxidil can boost hair growth but may cause side effects like heart palpitations and increased body hair. Many prefer topical minoxidil due to fewer side effects.

community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

129 upvotes 3 years ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

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