This study reports that patients with specific MFN2 mutations, including p.Arg707Trp, exhibit significant upper body fat overgrowth with suppressed leptin production, suggesting tissue-selective mitochondrial dysfunction and potential therapeutic targets.
This chapter examines how toxins such as inorganic arsenic, dioxin, and bacterial toxins can disrupt the balance of keratinocyte stem cell regeneration and differentiation, affecting skin barrier maintenance.
7 citations
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January 2002 in “PubMed” This study observed significant skin changes, including epidermal thickening and pleomorphic keratinocytes, in rats after subchronic UVB irradiation, highlighting specific reactions in the dorsal skin.
30 citations
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January 2001 in “Journal of the American Veterinary Medical Association” This study found that adrenal sex hormone levels were elevated in neutered dogs with hypercortisolemia, except for testosterone, highlighting the importance of ruling out hypercortisolemia when diagnosing adrenal hyperplasia syndrome.
30 citations
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January 1999 in “Dermatology” This study found that cyclosporine A may lead to partial hair regrowth in 50% of patients with severe alopecia areata who do not respond to standard treatments.
