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Did you mean 3β-Hydroxysteroid Dehydrogenase?

Glossary3β-Hydroxysteroid Dehydrogenase

enzyme crucial for converting steroid precursors into active hormones

3β-Hydroxysteroid Dehydrogenase (3β-HSD) is an enzyme that plays a crucial role in the biosynthesis of all classes of hormonal steroids, including androgens, estrogens, and glucocorticoids. It catalyzes the conversion of Δ5-3β-hydroxysteroids to Δ4-3-ketosteroids, a key step in the production of hormones that regulate various physiological processes, including hair growth and skin health.

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Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

research Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

20 citations , June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery”

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

research Structure and Expression of a New Complementary DNA Encoding the Almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4-Isomerase in Human Adrenals and Gonads

354 citations , August 1991 in “Molecular Endocrinology”

Human adrenals and gonads have a unique enzyme for steroid hormone production.

research Localization, Age- and Site-Dependent Expression, and Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Skin

119 citations , August 2010 in “Journal of Investigative Dermatology”

Increased 11β-HSD1 activity in skin may contribute to aging and could be targeted to reduce aging effects.

research Steroid 5α-Reductases and 3α-Hydroxysteroid Dehydrogenases: Key Enzymes in Androgen Metabolism

115 citations , March 2001 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

research Male Pseudohermaphroditism Due to 17β-Hydroxysteroid Dehydrogenase Deficiency: Studies on the Natural History of the Defect and Effect of Androgens on Gender Role

98 citations , July 1983 in “Journal of Steroid Biochemistry”

Individuals with this condition often develop male traits and identities at puberty despite being raised as females.

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community 3α-Hydroxysteroid dehydrogenase community driven study, not anytime soon guys.

in Research/Science 105 upvotes 4 years ago

High cost of studying 3α-Hydroxysteroid dehydrogenase in hair loss led to suggestions of crowdfunding for research. Users discussed using Procyanidin B2/melatonin topical treatment and tracking funds with blockchain.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 442 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community The theory that explains everything. Please help me make this big!

in Research/Science 2446 upvotes 4 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 1 year ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

community Minoxidil is NOT an Anti-androgen. No.

in Research/Science 43 upvotes 1 month ago

Minoxidil is not an anti-androgen; it is a growth stimulator and does not lower DHT like finasteride or dutasteride. Minoxidil can cause side effects like facial swelling and anxiety due to its vasodilator properties.

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