This paper discusses the clinical and histological aspects of skin aging, differentiating between endogenous and exogenous factors, and reports no new clinical findings.
26 citations
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February 2022 in “Journal of pineal research”
This review examines melatonin's potential effects on humanskin and hair follicle pigmentation, highlighting the need to confirm findings from cell cultures in physiological tissue contexts.
May 2021 in “Research journal of topical and cosmetic sciences”
In this study, oral supplementation of Microcore’s TrichovitalsTM significantly improved the appearance of facial skin, hair, and nails over 12 weeks in healthy middle-aged adults compared to a control group.
1 citations
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May 2021 in “Research journal of topical and cosmetic sciences”
This study observed that taking 500mg/day of Microcore’s Muttaijow ComplexTM for 12 weeks significantly improved the appearance of skin, hair, and nails in healthy middle-aged adults.
9 citations
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August 2017 in “Photochemistry and Photobiology”
This study found that isolated red light may serve as an alternative for photo-immunotherapy without additional photosensitizers, as it did not reduce keratinocyte differentiation markers or increase photo-oxidative damage, unlike treatment with IL-4 or UVA1/blue light.
Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.
Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.
PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.
Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.
PP405 and ABS-201 are promising treatments for male pattern baldness. PP405 shows rapid hair growth in human trials, while ABS-201 shows significant regrowth in animal studies but is still in early human trials.
Can long-term use of Fluocinolone affect the health of hair follicles?There is no long-term human trial measuring what topical fluocinolone does to hair follicles; what is documented is the label's warning about skin atrophy with prolonged use, plus a 2007 mouse study suggesting hair-follicle bulge stem cells do not repair steroid-induced atrophy.
What is GHK-Cu and why is it said to be a "miracle" for hair?GHK-Cu is a copper peptide studied mainly for wound healing and skin repair; for hair loss the evidence stops at cell-culture and animal work, and no published human trial has tested it for androgenetic alopecia.
Can latanoprost be safely applied to the scalp, or is it only for eyelashes?Latanoprost is not approved for use on the scalp and its safety there has not been established: the only human scalp evidence is one 24-week pilot trial in 16 men, and clinicians flag irritation, skin darkening and unknown absorption over a large area as open risks.