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research An efficient method for isolation of hair papillae and follicle epithelium from human scalp specimens

8 citations , September 1993 in “British journal of dermatology/British journal of dermatology, Supplement”

This study reports a new method for efficiently isolating hair papillae and follicle epithelium from human scalp specimens but presents no clinical results.

research Improvement of cell proliferation and antioxidant activity of silymarin in hair follicles dermal papillae isolated from the human scalp: Comparison with vitamin C effects

8 citations , January 2020 in “International Journal of Trichology”

Silymarin improves hair follicle health better than vitamin C by boosting cell growth and reducing oxidative stress.

research Scalp condition improvement with botanical extracts possessing chemical and physical antioxidant activity

November 2024 in “International Journal of Cosmetic Science”

This study demonstrated that several botanical extracts possess antioxidant properties, reducing oxidative stress and lipid oxidation in scalp treatments, with rosemary extract showing potential to improve scalp condition in a 4-week consumer trial.

research LB1017 A novel link between human hair follicle neuroimmunology and mitochondrial biology: Substance P increases intrafollicular oxidative stress and mitochondrial biogenesis

July 2022 in “Journal of Investigative Dermatology”

This study found that Substance P increased mitochondrial activity and biogenesis markers in cultured human scalp hair follicles, suggesting a novel link between stress-related neuropeptide signaling and hair follicle mitochondrial responses.

research N1-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles

13 citations , July 2015 in “Archives of dermatological research”

This study found that the spermidine analog N1-methylspermidine prolonged hair follicle growth and decreased inflammation and oxidative stress in cultured hair follicles, suggesting potential relevance for treating inflammatory scalp diseases.

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Community Join

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Prevention of age-related beard graying in humans by the topical application of Eriodictyon angustifolium extract

5 upvotes 4 years ago

Topical application of Eriodictyon angustifolium extract can prevent and reverse age-related beard graying and darken gray hair by increasing melanin production. Sterubin, a component of the extract, also promotes hair pigmentation and protects cells from DNA damage.

community Possible natural pp405 solution

in Research/Science 45 upvotes 1 year ago

Rotenone, a natural plant extract, may promote hair growth by increasing LDH activity and blocking MPC in the scalp, but it carries risks due to its toxicity. The suggested formulation includes Barbasco extract, DMSO, propylene glycol or PEG-400, ethanol, and a carrier oil.

community Why did this recent research paper from professor Tsuji lab in Japan largely go unnoticed by this sub? Isn't this discovery huge? (hair cloning)

35 upvotes 4 months ago

A recent discovery in hair cloning identified a previously unknown cell type essential for hair follicle growth, which could potentially make lab-grown hair viable if translated to humans. However, skepticism remains due to past delays and the challenges of replicating results in humans and making the process affordable.

community Innovative hair loss treatment can restore 90% of lost hair

890 upvotes 2 years ago

A new hair loss treatment using dermal exosomes can restore up to 90% of lost hair in mice. Users discuss potential human trials and compare it to Minoxidil and Finasteride.

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Learn

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learn Ginkgo biloba

Does ginkgo biloba improve scalp circulation, and does that help hair regrowth? No human study has shown that ginkgo improves scalp circulation or regrows hair; the direct hair evidence is a 1993 mouse study. Ginkgo may increase bleeding risk, especially with blood thinners.
Can ginkgo biloba reduce scalp inflammation that contributes to hair loss? There is no human evidence that ginkgo reduces scalp inflammation or helps hair loss. Ginkgo may increase bleeding risk and interact with medicines, so talk to a doctor or pharmacist first.

learn Pumpkin seed oil

Does pumpkin seed oil help improve scalp health and reduce inflammation? No human study has measured whether pumpkin seed oil reduces scalp inflammation. The one hair trial, funded by the capsule supplier, did not look at inflammation.

learn Vitamin C

Is topical Vitamin C effective for scalp and hair growth? No human trial has shown that topical vitamin C improves hair growth or scalp health. Its skin trials were on other body sites, and the hair data come from laboratory studies.

learn Vitis vinifera

Can grape extract help with scalp circulation or hair growth? There is no human evidence that grape extract improves scalp blood flow or hair growth; the related data are on blood pressure and in mice.

learn Lavender

Plant essential oil used in scalp products

learn Alfatradiol

Weak form of estrogen applied to the scalp

learn Minoxidil

Vasodilator used on the scalp and, at low doses, as a tablet

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Clinics

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Experts

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Trichologist
Kirsten J. Scalp
Greenville, SC, United States

Kirsten J. Scalp