A potential non-invasive topical treatment targeting the WNT Signaling Pathway for hair regeneration is being researched, with positive results on humanhairfolliclecells. Current effective treatments for hair loss include Minoxidil, finasteride, and hair transplantation.
The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.
N-Acetyl-Cysteine (NAC) was found to improve hair parameters in men with early-onset androgenetic alopecia, showing increased terminal hair count and decreased vellus hair count, with good tolerability. NAC, used alone or with minoxidil, may help due to its antioxidant properties, though its effectiveness can vary among individuals.
A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hairfolliclecell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.