39 citations
,
October 2013 in “Plastic and Reconstructive Surgery” In this study, researchers found that intestine-derived human alpha defensin 5 enhances wound healing, reduces bacterial load, and promotes hair growth in murine burn wound beds by increasing LGR stem cell migration.
1 citations
,
December 2012 in “Papers on Anthropology” This study found that psoriatic skin lesions commonly express the cytokines IL-6, IL-8, and TNF-alpha along with a moderate presence of the antimicrobial protein defensin.
3 citations
,
September 2016 in “Clinical, cosmetic and investigational dermatology” This study found that sphinganine may improve scalp health, hair quality, and reduce hair loss in males, potentially due to increased antimicrobial peptide levels and inhibition of 5-α-reductase.
195 citations
,
December 2009 in “Journal of Investigative Dermatology” This study found that sebum free fatty acids may enhance the antibacterial defense of human sebaceous glands by upregulating the expression of the antimicrobial peptide hBD-2, potentially aiding in acne treatment.
23 citations
,
August 2018 in “Facial Plastic Surgery Clinics of North America” This review discusses the role of defensin peptides in stem cell activation for potential skin rejuvenation therapies and reports no new clinical findings, emphasizing the need for further studies.