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research Impact of CDK4/6 inhibitors on health-related quality of life outcomes in patients with metastatic breast cancer: A systematic review and meta-analysis

1 citations , November 2025 in “Journal of Managed Care & Specialty Pharmacy”

This study concluded that while CDK4/6 inhibitors, used to treat HR+ HER2- metastatic breast cancer, generally did not worsen health-related quality of life, they were associated with increased patient-reported issues like diarrhea and hair loss upset.

research Sex Hormones and Related Compounds, Including Hormonal Contraceptives

January 2015 in “Side effects of drugs annual”

This review discusses various sex hormones and related compounds, including estrogens and anabolic steroids, but reports no new findings; it highlights existing literature from 2014 regarding their use and effects.

research A systematic review of health-related quality of life outcomes in patients with advanced breast cancer treated with palbociclib

7 citations , September 2024 in “Journal of Comparative Effectiveness Research”

This study reports that health-related quality of life was generally maintained, and sometimes improved, in patients with HR+/HER2- advanced or metastatic breast cancer treated with palbociclib, compared to monotherapy, across various study types.

research A correlation of breast cancer and calcium levels in hair analyzed by X-ray fluorescence

8 citations , September 2014 in “Journal of X-Ray Science and Technology”

This study found that hair analysis may be useful in early breast cancer detection by identifying distinct calcium and strontium concentration patterns before and during cancer development.

research Hair loss in the elderly

November 2011

This review discusses types of hair loss in elderly women, highlighting diagnostic challenges and treatment limitations, but does not present new research findings.

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community Terminal hairs growing in, but derm still says I’m going to go bald in the years to come??

in Chat 5 upvotes 1 year ago

A 30-year-old woman with a history of anemia and low vitamin D experienced hair shedding, which improved after addressing nutrient deficiencies. Despite regrowth of terminal hairs, her dermatologist recommended treatments like minoxidil and spironolactone to prevent future bald spots, but she is cautious due to family history of hormone-related cancers.

community Amplifica Sees Positive Results for Hair Loss Treatment - Results Show 15% increase in 60 days!

103 upvotes 1 year ago

Amplifica's new injectable treatment for androgenetic alopecia shows a 15% increase in hair thickness and coarseness in 60 days. The treatment is in early human trials and offers a promising alternative to hormone-related hair loss treatments.

community Evolution theory: AGA is your body trying to reduce the risk of prostate cancer by exposing your scalp to more UV

in Research/Science 9 months ago

Androgenic alopecia (AGA) might have evolved to reduce prostate cancer risk by increasing UV exposure to the scalp, but this theory is debated. Treatments like minoxidil and finasteride are used for AGA, though the exact causes and evolutionary reasons for hair loss are unclear.

community Why does the same hormone grow your beard and destroy your hairline?

44 upvotes 4 months ago

DHT promotes beard growth but causes scalp hair loss due to inflammation and fibrosis. Treatments like finasteride and minoxidil help with hormonal signals and blood flow but don't address underlying inflammation.

community Finasteride - impact on Neurosteroids, which yes, \are important and not a garbage hormone

in Research/Science 163 upvotes 1 year ago

Finasteride may affect neurosteroids, impacting mood and sexual function, with varied user experiences. Some report side effects like depression and sexual dysfunction, while others find it effective for hair retention or prefer alternatives like Dutasteride or topical treatments.

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learn Estradiol

Estrogen hormone, prescribed in tablet, patch and gel forms

Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? There are no good-quality trials showing that estradiol applied to the scalp treats hormone-related thinning. Skin-applied estradiol can still enter the bloodstream and pass to others through contact.
Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol is used within supervised hormone therapy and may slow hormone-related hair loss in some women and trans women, but the evidence is limited and it carries serious whole-body risks.

learn Bicalutamide

Nonsteroidal anti-androgen, originally a prostate cancer drug

learn Dutasteride

5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

learn Centella

Hormone-related scalp sensitivity: is there evidence for a centella mask? Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

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