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research Androgenetic alopecia: effects of oral finasteride on hormone profile, reproduction and sexual function

10 citations , February 2020 in “Endocrine”

This study found that finasteride treatment in males with androgenetic alopecia was linked to significant changes in sperm parameters and increased testosterone levels, but no sexual dysfunction was observed, and sperm parameters returned to baseline after treatment stopped.

research Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles

95 citations , August 2013 in “Journal of Investigative Dermatology”

HPT axis hormones boost mitochondrial function and growth in hair follicles, potentially aiding hair health.

research Simultaneous determination of 30 hormones illegally added to anti-ageing functional foods using UPLC-MS/MS coupled with SPE clean-up

6 citations , September 2014 in “Food Additives & Contaminants: Part A”

This study developed a new method for detecting 30 hormones in anti-aging functional foods, demonstrating good sensitivity and reliability, and identified seven hormones in four out of 14 samples tested.

research 457 Impact of alpha-melanocyte-stimulating hormone on mitochondrial function in human dermal fibroblasts

November 2025 in “Journal of Investigative Dermatology”

Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.

research Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of α-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells

60 citations , August 2005 in “Endocrinology”

This study suggests that αMSH may play a regulatory role in human dermal papilla cells, potentially influencing immune and inflammatory responses in hair follicles, which could contribute to inflammatory alopecia.

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Clinics

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community Finasteride - impact on Neurosteroids, which yes, \are important and not a garbage hormone

in Research/Science 163 upvotes 1 year ago

Finasteride may affect neurosteroids, impacting mood and sexual function, with varied user experiences. Some report side effects like depression and sexual dysfunction, while others find it effective for hair retention or prefer alternatives like Dutasteride or topical treatments.

community 11 months progress, HRT + Fin + Min

in Progress Pictures 366 upvotes 6 months ago

A transwoman shared her 11-month progress using hormone replacement therapy (HRT), finasteride, and minoxidil, reporting significant hair regrowth and satisfaction with the results. The discussion included various perspectives on HRT, its effects on hair and sexual function, and personal experiences with similar treatments.

community What Private blood test should I take?

9 upvotes 2 years ago

A user in the UK seeks advice on blood tests before starting Finasteride and Minoxidil for hair loss. Recommended tests include thyroid function, hormone levels, liver and kidney function, and vitamin and mineral levels.

community CHECKLIST: Blood and other test before starting treatment

4 upvotes 2 years ago

Before starting hair loss treatment, it's suggested to undergo various blood and health tests to minimize side effects. The checklist includes tests for kidney function, liver enzymes, blood sugar, vitamins, hormones, and more.

community Hormone Management Advice - Aromatase Inhibitors , SHBG Blockers

in Finasteride/Dutasteride 5 upvotes 1 year ago

The user plans to switch from minoxidil to finasteride or dutasteride for hair loss, while managing hormones with aromatase inhibitors and SHBG blockers. They seek advice on the best options for these treatments, considering past side effects and future therapies.

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Learn

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learn Melatonin

Hormone that regulates sleep, sold as a supplement

learn Estradiol

Estrogen hormone, prescribed in tablet, patch and gel forms

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol is used within supervised hormone therapy and may slow hormone-related hair loss in some women and trans women, but the evidence is limited and it carries serious whole-body risks.
Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? There are no good-quality trials showing that estradiol applied to the scalp treats hormone-related thinning. Skin-applied estradiol can still enter the bloodstream and pass to others through contact.

learn Bicalutamide

Nonsteroidal anti-androgen, originally a prostate cancer drug

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Centella

Hormone-related scalp sensitivity: is there evidence for a centella mask? Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

learn procapil

Does Procapil block DHT without affecting hormones? What the evidence shows Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

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