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GlossaryHLA-DQ

protein complex involved in immune system antigen presentation

HLA-DQ is a protein complex that plays a crucial role in the immune system by helping the body distinguish between its own cells and foreign invaders. It is part of the human leukocyte antigen (HLA) system, specifically involved in presenting antigens to immune cells, which is essential for initiating an immune response. Variations in HLA-DQ genes are associated with susceptibility to certain autoimmune diseases, including type 1 diabetes and celiac disease.

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research Genetic Association of HLA-DQB1 and HLA-DRB1 Polymorphisms with Alopecia Areata in the Italian Population

35 citations, June 2011 in “British Journal of Dermatology”

The DQB1*03 allele is linked to higher alopecia areata risk in Italians.

research Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

36 citations, July 2007 in “Journal of Investigative Dermatology”

Certain HLA class II alleles increase or decrease the risk of alopecia areata.

Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review

research Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review

1 citations, June 2023 in “Genes”

Hair loss from Alopecia Areata is caused by both genes and environment, with several treatments available but challenges in cost and relapse remain.

Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata

research Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata

32 citations, March 2015 in “The Journal of Clinical Endocrinology & Metabolism”

Alopecia areata is linked to thyroid autoimmunity but not type 1 diabetes.

research Exomic Sequencing of Immune-Related Genes Reveals Novel Candidate Variants Associated with Alopecia Universalis

18 citations, January 2013 in “PLoS ONE”

HLA-DRB5 and other genes may be linked to alopecia universalis.

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