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Did you mean Hair Shaft Abnormality?

Glossary Hair Shaft Abnormality

irregular or defective hair structure causing fragility and breakage

Hair Shaft Abnormality, also known as Hair Shaft Disorder, refers to a range of conditions where the structure of the hair shaft is irregular or defective. These abnormalities can lead to hair that is fragile, prone to breakage, or has an unusual appearance, such as twisting, kinking, or splitting. Causes can be genetic, environmental, or due to underlying health issues, and diagnosis often involves microscopic examination of the hair.

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Research

5 / 1000+ results

research Hair Shaft Abnormalities. Pili Bifurcati: A Scanning Electron Microscopy Analysis

5 citations , March 2009 in “Pediatric Dermatology”

The study found that pili bifurcati causes hair to intermittently split into two branches, each with its own outer layer.

research Regenerative Potential of Adipose Tissue–Derived Exosomes in Treating Hair Shaft Abnormalities: A Case Report

January 2025 in “Case Reports in Dermatological Medicine”

This report describes an eight-year-old girl with severe hair shaft abnormalities who showed significant improvement after a single session of adipose tissue–derived exosome therapy, highlighting its potential as an innovative treatment option and the need for further studies to confirm its efficacy and safety.

research Hair Shaft Abnormalities – Clues to Diagnosis and Treatment

44 citations , January 2005 in “Dermatology”

This article reviews the clinical and diagnostic features of hair shaft disorders, emphasizing the role of structured patient assessments and the avoidance of hair trauma, but reports no new results.

research Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency

23 citations , February 2015 in “The American journal of pathology”

This study found that the absence of sebaceous glands may be an early factor in the development of keratosis pilaris, leading to hair shaft and skin barrier abnormalities, independent of filaggrin mutations.

research Lamellar ichthyosis, dwarfism, mental retardation, and hair shaft abnormalities

61 citations , April 1980 in “Journal of the American Academy of Dermatology”

This case study describes a young woman with a unique syndrome combining lamellar ichthyosis, neuroectodermal and mesodermal defects, and hair with trichoschisis and low sulfur content.

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Community Join

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community Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive

6 upvotes 1 month ago

Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community Most Promising Future Hair Loss Treatments In 2026

83 upvotes 1 week ago

Promising hair loss treatments in 2026 include GT20029, a topical androgen receptor degrader, and VDPHL01, an extended-release oral minoxidil, both offering safer alternatives with fewer side effects. Other treatments like sublingual minoxidil, OND-1, JW0061, TDM-105795, and AMP-303 are also being explored.

community Cbum's hair transplant looks absolutely terrible

979 upvotes 1 year ago

A bodybuilder's hair transplant appears unnatural with a straight hairline and low density, possibly worsened by not using finasteride. The Turkish clinic is criticized for poor design, and the transplant may have been free for promotion.

community I can’t believe it’s actually coming back

907 upvotes 10 months ago

A user experienced positive hair regrowth after 9 months using Dutasteride (0.5mg daily) and oral Minoxidil (2.5mg daily) without side effects and plans a hair transplant. They noted the cost-effectiveness of oral Minoxidil and discussed hair loss treatments, including Finasteride.

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Learn

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learn Cetirizine

How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.