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research Effect and mechanism of YH0618 granule on chemotherapy- induced hair loss in patients with breast cancer: study protocol for a randomized, double-blind, multi-center clinical trial

January 2019 in “Research Square (Research Square)”

In this study, researchers will conduct a randomized, double-blind, multi-center clinical trial to assess the effectiveness of YH0618 granule in preventing chemotherapy-induced hair loss among breast cancer patients, aiming to understand its mechanism related to kidney deficiency in Chinese Medicine. Results are not yet reported.

research From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber

81 citations , April 2009 in “Journal of Investigative Dermatology”

This review discusses the shedding phase of the hair cycle, known as exogen, and reports no new findings while analyzing related processes like club fiber formation and release.

research The effect and mechanism of YH0618 granule on chemotherapy- induced hair loss in patients with breast cancer: study protocol for a randomized, double-blind, multi-center clinical trial

4 citations , December 2019 in “Trials”

This study aims to evaluate the effectiveness of YH0618 granules in preventing chemotherapy-induced hair loss in breast cancer patients through a randomized, double-blind, multi-center clinical trial, focusing on potential mechanisms related to kidney deficiency as understood in Chinese Medicine. Results are not yet reported.

research 194 An underlying mechanism of hair loss in acrodermatitis enteropathica

August 2016 in “Journal of Investigative Dermatology”

In this animal study, zinc deficiency in mice was linked to disrupted hair cycles and impaired hair regrowth, which were reversed by zinc supplementation.

research Technological Advances in Anti-hair Loss and Hair Regrowth Cosmeceuticals: Mechanistic Breakthroughs and Industrial Prospects Driven by Multidisciplinary Collaborative Innovation

August 2025 in “Aesthetic Plastic Surgery”

This review explores the mechanisms, current products, challenges, and innovative approaches related to cosmetics for hair loss prevention and growth promotion, emphasizing the need for multidisciplinary cooperation to enhance product development and market success.

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community Another mechanism to hair loss that isn’t talked about. Heavy metals and follicle waste.

16 upvotes 3 months ago

Hair follicles can store waste, potentially leading to hair loss, and treatments like DHT blockers and Minoxidil are suggested. Scalp inflammation and sensitivity to DHT also contribute to hair loss, and addressing these factors with a clinician is recommended.

community Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive

6 upvotes 2 months ago

Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.

community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community Possible mechanism for creatine to induce hair loss identified

12 upvotes 3 years ago

Creatine may affect hair loss by reducing PGE2 levels, which could influence hair growth. The discussion highlights the need for more research on this potential mechanism.

community It's very ironic that many guys will gaslight you that your hair loss does not matter but unconsciously in another sentence they will recommend you a giant compensation mechanism like becoming a bodybuilder or a multimillionaire.

in Chat 419 upvotes 1 year ago

Hair loss matters, but focusing on self-improvement like working out, using treatments like minoxidil and finasteride, and building confidence can help. People often suggest extreme solutions like becoming a millionaire or bodybuilder, but practical steps are more beneficial.

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Learn

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learn Valproic acid

What biological mechanisms related to hair follicles are linked to valproic acid in experimental treatments? In cell and mouse studies, valproic acid alters signalling linked to hair growth. This has not been shown to help people outside one small trial, and oral valproate carries a boxed warning and can itself cause hair loss.

learn Botox

Can relaxing your scalp with Botox help reverse hair loss? Botox for hair loss is off-label and experimental: small uncontrolled studies report hair-count gains, but there is no placebo-controlled trial, and the proposed blood-flow mechanism has not been measured. All botulinum toxin products carry an FDA boxed warning about spread of the toxin effect.
How does Botox target the tension that may be blocking your hair growth? Botox for hair loss is experimental and off-label: one small open-label pilot study of 50 men reported an 18% hair-count increase, but there is no placebo-controlled trial and the proposed scalp blood-flow mechanism has never been measured in patients.

learn Folic acid

How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.

learn Rapamycin

Can rapamycin be combined with other treatments like minoxidil or finasteride for better results? There are no published human trials of rapamycin combined with minoxidil or finasteride; the case for combining them is mechanistic theory only, and rapamycin for hair loss remains an off-label use of an immunosuppressant, so any combination is a decision for a prescriber.