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Alopecia Areata Susceptibility Variant Identified by MHC Risk Haplotype Sequencing Reproduces Symptomatic Patched Hair Loss in Mice

research Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice

April 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study identified a specific genetic variant in the CCHCR1 gene that may contribute to alopecia areata through impaired keratinization, suggesting an alternative mechanism beyond autoimmune causes.

research Quality issues identified in systematic reviews on platelet‐rich plasma therapy for pattern hair loss—A method study

December 2019 in “Journal of cosmetic dermatology”

This study identified various methodological inconsistencies in systematic reviews on platelet-rich plasma therapy for pattern hair loss, suggesting a need for rigorous adherence to established guidelines.

research Identification of Stress-Related Hair Loss and Prevention Through the Application of a KNN Model Based on Machine Learning

August 2025 in “International Journal of Research Publication and Reviews”

This study suggests that stress intensity is highly correlated with hairfall severity, highlighting the potential of an inexpensive and accessible machine learning approach for forecasting and prevention.

research Hair Loss and the Applied Techniques for Identification of Novel Hair Growth Promoters for Hair Re-Growth

6 citations , May 2011 in “Pharmacognosy Journal”

This review discusses the causes of alopecia, including androgenetic alopecia, and potential active ingredients for hair regrowth, but it does not report new clinical results.

research Male-pattern hair loss: Comprehensive identification of the associated genes as a basis for understanding pathophysiology

April 2023 in “Medizinische Genetik”

This review discusses the current status of genetic research on male-pattern hair loss and reports no new findings, outlining significant achievements and future challenges in understanding its biology and treatment.

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Community Join

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community Possible mechanism for creatine to induce hair loss identified

12 upvotes 3 years ago

Creatine may affect hair loss by reducing PGE2 levels, which could influence hair growth. The discussion highlights the need for more research on this potential mechanism.

community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

263 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.

community Hairloss - what hormones to check?

9 upvotes 2 years ago

The user is concerned about hair loss despite using oral finasteride, oral minoxidil, and topical minoxidil. They are seeking advice on additional blood tests to identify potential causes.

community Ray Peat: Testosterone Isn’t the Culprit, Prolactin and Cortisol Drive Hair Loss (2016)

in Research/Science 110 upvotes 10 months ago

Prolactin and cortisol are identified as key factors in hair loss, with stress hormones impacting hair shedding. Finasteride and minoxidil are effective treatments, while DHT's role and individual sensitivity are significant factors.

community What I hate about being told to shave my head

in Chat 258 upvotes 1 year ago

Hair loss challenges and identity issues, with opinions on using finasteride, minoxidil, and hair transplants versus accepting baldness. Some find shaving more work, while others stress personal choice and self-perception.

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Learn

8 / 66 results

learn Hair Transplant

Will people be able to tell I had a hair transplant? Most people won't notice a hair transplant if done by a skilled surgeon.
What is shock loss after a hair transplant? Shock loss is temporary hair shedding after a transplant, usually resolving in a few months.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn GHK-Cu

a copper peptide showing promise in both regrowth and reversing gray hair

learn Vitamin D

vitamin you should probably be taking for general health might also help your hair a little

How can I tell if my hair loss is linked to low Vitamin D levels? Hair loss may indicate low Vitamin D levels, but testing is needed for confirmation.

learn Platelet-Rich Plasma

Are Platelet results permanent, or does hair loss return once treatment stops? Hair loss typically returns after stopping PRP treatment, as effects are not permanent.

learn Vitamin B12

How can you tell if your hair loss is related to low Vitamin B12 levels? Hair loss may indicate low Vitamin B12 if accompanied by fatigue and anemia symptoms.

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Clinics

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