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research Trypsin-induced follicular papilla apoptosis results in delayed hair growth and pigmentation

29 citations , April 1997 in “Developmental Dynamics”

This study found that topical trypsin application after hair removal in mice led to cell death at the follicular papilla, which delayed hair growth and pigmentation.

research Human follicular stem cells: their presence in plucked hair and follicular cell culture

82 citations , May 2004 in “British Journal of Dermatology”

This study found CK19/Bcl-2-positive and Bax-negative cells in hair follicle cultures from plucked hairs, supporting their potential identification as follicular stem cells located in the bulge area.

research Stem cell apoptosis in HIV‐1 alopecia

15 citations , August 2006 in “Journal of Cutaneous Pathology”

This study found that diffuse alopecia in HIV-1-infected patients is characterized by higher rates of follicular stem cell apoptosis compared to controls, suggesting a hair cycle disturbance associated with the infection.

research Mechanism of Apoptotic Regulation of Follicular Regression

2 citations , June 2001 in “American Journal of Pathology”

This article explores the complexity and significance of the hair follicle, emphasizing new insights into its biological roles and the involvement of p53 in follicular regression.

research Apoptosis in Hair and Skin: A Review

2 citations , August 2019 in “Journal of skin and stem cell”

This review discusses how targeting apoptosis pathways in hair and skin cells can inform the development of novel therapies, but it reports no clinical findings.

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community Short Peptides for Hair Loss: anyone tried any of these?

14 upvotes 5 months ago

Various peptides are discussed for treating male pattern baldness, with some available for topical use like GHK-Cu and Ac-KGHK, while others remain in research stages. Users are interested in experiences and sourcing these treatments.

community Possible topical option for preventing BDNF-related hair loss

6 upvotes 2 years ago

The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.

community A Theory on Why Microneedling Works

175 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community What if DHT is not the vilan.

13 upvotes 5 years ago

Hair loss may be influenced more by inflammation, microbiome imbalances, and gut health than DHT. Treatments discussed include minoxidil, finasteride, RU58841, fecal microbiota transplants, and JAK inhibitors.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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