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Autoantigen Discovery in the Hair Loss Disorder, Alopecia Areata: Implications of Post-Translational Modifications

research Autoantigen Discovery in the Hair Loss Disorder, Alopecia Areata: Implication of Post-Translational Modifications

11 citations , June 2022 in “Frontiers in immunology”

This review discusses the challenges in identifying specific hair follicle antigens involved in initiating alopecia areata and highlights the need for further research to understand its etiopathogenesis, reporting no new results.

research Eosinophilic folliculitis of the scalp associated with PD‐1/PDL1 inhibitors

9 citations , April 2020 in “Journal of Cosmetic Dermatology”

This case report describes the first instance of eosinophilic folliculitis of the scalp occurring during nivolumab therapy, which responded partially to topical steroids and cream but did not require stopping the treatment.

research 307 Computer-assisted epitope prediction revealed potential autoantigens associated with human alopecia areata

April 2018 in “Journal of Investigative Dermatology”

In this study, researchers observed that alopecia areata patients showed higher Th1 and Th2 responses against specific melanogenesis-related protein epitopes, suggesting a role in disease activity and potential targets for diagnostics and therapies.

research Alopecia areata possibly induced by autoimmune reaction in a patient with human T‐cell lymphotropic virus‐1‐associated myelopathy

6 citations , May 2013 in “The Journal of Dermatology”

This case study suggests that autoimmunity involving cytotoxic CD8+ T cells may link alopecia areata and human T-cell lymphotropic virus-1-associated myelopathy in adult T-cell leukemia/lymphoma patients.

research Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles

1 citations , September 2023 in “Clinical, cosmetic and investigational dermatology”

This genome-wide association study identified several genetic markers, including specific SNPs and HLA genotypes, associated with alopecia areata susceptibility in the Taiwanese population, highlighting key pathways involved in immune response and offering insights into the genetic origins of this autoimmune condition.

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Community Join

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community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

129 upvotes 3 years ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

community Thoughts on Pre-Finasteride Bloodwork? Normal/high Total and Free Testosterone, Low DHEA-S?

5 upvotes 4 years ago

A 23-year-old male is considering starting Finasteride for hair loss after experiencing persistent shedding and hairline recession, with bloodwork showing normal testosterone levels but low DHEA-S and Vitamin D. He plans to discuss DHEA supplementation with his doctor and has already started Vitamin D supplementation.

community Dutasteride is way more effective than Finasteride (Study)

in Research/Science 184 upvotes 1 year ago

Dutasteride is more effective than Finasteride for hair loss, with similar safety profiles. Individual responses vary, and factors like Minoxidil use and age differences may influence results.

community Another mechanism to hair loss that isn’t talked about. Heavy metals and follicle waste.

16 upvotes 2 months ago

Hair follicles can store waste, potentially leading to hair loss, and treatments like DHT blockers and Minoxidil are suggested. Scalp inflammation and sensitivity to DHT also contribute to hair loss, and addressing these factors with a clinician is recommended.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001).

297 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%, and type 2 diabetes is linked to female pattern hair loss. Reducing sugar intake and using treatments like finasteride and minoxidil may help manage hair loss.

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Learn

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learn Overview

learn Hair Transplant

What is Follicular Unit Extraction (FUE) in hair transplants? Follicular Unit Extraction (FUE) is a minimally invasive hair transplant method that extracts individual hair follicles.
What is a hair transplant? A hair transplant is a surgical procedure that relocates hair follicles to areas of thinning.

learn Verteporfin

chemical that might completely regrow follicles from hair transplant extractions

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Caffeine

the stimulant you know and love can be used topically to stimulate hair

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Niacinamide

How does Niacinamide support the hair follicle’s nutrition? Niacinamide nourishes hair follicles by boosting energy production and supporting antioxidant defenses.

learn oleic acid

How does Oleic Acid support hair follicle strength and growth? Oleic acid strengthens hair follicles by enhancing hydration and reducing inflammation.

learn zinc PCA

Why is zinc important for preventing hair loss and supporting hair follicle function? Zinc is crucial for hair follicle health, supporting growth and repair processes.

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Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas