Search

for
Search:

Research

5 / 1000+ results

research Responses of hair follicle–associated structures to loss of planar cell polarity signaling

29 citations , February 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that Merkel cell clusters require Frizzled6 signaling for their polarity information, while other hair follicle-associated structures align their orientation based on the hair follicle itself.

research Characterization of response of murine hair follicle-derived keratinocyte against androgen and testosterone 5α-redactase activity

August 1994 in “Journal of dermatological science”

Mouse hair cells respond to male hormones by growing less, and this can be stopped by certain blockers.

research Ability to culture dermal papilla cells from red deer (Cervus elaphus) hair follicles with differing hormonal responses in vivo offers a new model for studying the control of hair follicle biology

16 citations , August 1996 in “The journal of experimental zoology/Journal of experimental zoology”

This study suggests that red deer stags provide a novel model for investigating hormonal regulation of hair growth due to the different cell growth rates in hair follicles during breeding and nonbreeding seasons.

research [Effects of immune responses mediated by topological structures of three-dimensional bioprinted scaffolds on hair follicle cycle in mice].

January 2024 in “PubMed”

This study investigated how different 3D bioprinted scaffold structures affect immune responses and hair growth in mice, finding that moderate immune response induced by certain structures stimulates hair growth, while excessive immune response can hinder hair follicle development.

research Author response: Coordinated hedgehog signaling induces new hair follicles in adult skin

December 2019

In this study, activation of Hedgehog signaling in both epithelial and stromal cells induced new hair follicles in adult mouse skin, but also resulted in the formation of tumors.

View more "hair follicle responses" in research →

Community Join

5 / 1000+ results

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 1 year ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community Intermittent fasting reduces hair growth?!? :(

35 upvotes 1 year ago

Intermittent fasting may inhibit hair growth by triggering a stress response that affects hair-follicle stem cells. Some users believe genetics and DHT play a larger role in hair loss, and treatments like Minoxidil and Finasteride are mentioned as ineffective for some.

community Just tell me that PP405 is gonna work I don't need any other responses

11 upvotes 1 year ago

PP405 is expected to work for hair regrowth by reactivating stem cells in hair follicles, with FDA approval anticipated in 2027-28. Users express both optimism and skepticism about its effectiveness and the lengthy approval process.

community DUPA, Non Responders and Connective Tissue Disorders

8 upvotes 1 year ago

A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 2 years ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

View more "hair follicle responses" in community →

Learn

10 / 61 results

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Caffeine

Stimulant used in hair shampoos and lotions

learn Microneedling

Technique that makes tiny punctures in the scalp with fine needles

learn Platelet-Rich Plasma

Concentrate of your own blood platelets, injected into the scalp

learn Thymosin Beta 4

learn Niacinamide

Does niacinamide support hair follicle nutrition? Niacinamide is a precursor of NAD+, a molecule cells use for energy. Whether it affects hair follicles in people has not been tested.

learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Providers say SMP sits above the hair follicles and does not harm them. No study has tested this, and infection or scarring from any tattoo can affect the skin.

learn Sulforaphane

Can sulforaphane protect hair follicles from inflammation and damage? In lab and mouse studies, sulforaphane reduced markers of inflammation and oxidative stress. No human study has tested whether it protects hair follicles.

learn Fluridil

Can daily Fluridil application stop hair follicle miniaturization? The single published fluridil trial (43 men; placebo-controlled for 3 months, then all on fluridil to 9 months) reported more hairs in the growth phase, but it never measured follicle diameter and has not been replicated — so whether daily use stops miniaturization is unproven, and community users describe stabilization rather than regrowth.

learn Folic acid

How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.

View more "hair follicle responses" in learn →

Clinics

6 / 13 results

All 13 clinic results →

Experts

1 / 5 results

SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas